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Hippo signaling in regeneration and aging.
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Abstract
The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage. In addition, YAP/TAZ are promising targets for regenerative medicine, as artificially increasing YAP/TAZ activity can be used to stimulate tissue regeneration, even in tissues that otherwise have little ability to regenerate. We will summarize here how YAP/TAZ could be used in regenerative medicine and how these two transcriptional regulators have been linked to aging so far.