Contributors
Shiao-Pieng Lee: Role: ConceptualizationRole: Funding acquisitionRole: Resources
Chen-Yu Kao: Role: ConceptualizationRole: InvestigationRole: Resources
Shun-Cheng Chang: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Resources
Yi-Lin Chiu: Role: Data curationRole: Formal analysis
Yen-Ju Chen: Role: Data curationRole: Formal analysisRole: Investigation
Ming-Hsing G. Chen: Role: Data curationRole: Formal analysis
Chun-Chia Chang: Role: Data curationRole: Formal analysisRole: Investigation
Yu-Wen Lin: Role: Data curation
Chien-Ping Chiang:
ORCID: http://orcid.org/0000-0003-3075-2118
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: Writing – review & editing
Jehng-Kang Wang: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
Methodology
Chen-Yong Lin:
ORCID: http://orcid.org/0000-0002-6391-2571
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: Writing – original draftRole: Writing – review & editing
Michael D. Johnson: Role: ConceptualizationRole: Formal analysisRole: Writing – review & editing
Mohammad Saleem: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
13
February
2018
Publication date Collection: 2018
Volume: 13
Issue: 2
Electronic Location Identifier: e0192632
Affiliations
[1
]
School of Dentistry, National Defense Medical Center, Taipei, Taiwan
[2
]
Department of Dentistry, Tri-Service General Hospital, Taipei, Taiwan
[3
]
Graduate Institute of Biomedical Engineering, National Taiwan University of Science
and Technology, Taipei, Taiwan
[4
]
Department of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan
[5
]
Division of Plastic Surgery, Department of Surgery, Shuang-Ho Hospital, Taipei, Taiwan
[6
]
Department of Surgery, School of Medicine, Taipei Medical University, Taipei, Taiwan
[7
]
Department of Biochemistry National Defense Medical Center, Taipei, Taiwan
[8
]
Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University
Washington DC, United States of America
[9
]
School of Medicine, National Defense Medical Center, Taipei, Taiwan
[10
]
Department of Dermatology, Tri-Service General Hospital, Taipei, Taiwan
University of Minnesota Hormel Institute, UNITED STATES
Author notes
Competing Interests: C.-Y.L. is an inventor on US patents #6,077,938 (Title: Monoclonal antibody to an
80-kDa protease) and #6,677,377 (Title: Structure based discovery of inhibitors of
matriptase for the cancer diagnosis and therapy by detection and inhibition of matriptase
activity) and M.D.J. and C.-Y.L. are inventors on US patent #7,355,015 (Title: Matriptase,
a serine protease and its applications). This does not alter our adherence to PLOS
ONE policies on sharing data and materials. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the manuscript.
Author information
Article
Publisher ID:
PONE-D-17-32068
DOI: 10.1371/journal.pone.0192632
PMC ID: 5811018
PubMed ID: 29438412
SO-VID: d5c12fef-a889-4b7a-b133-8d263885b5a2
Copyright © © 2018 Lee et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 6
September
2017
Date
accepted
: 26
January
2018
Page count
Figures: 7,
Tables: 0,
Pages: 18
Funding
Funded by: Tri-Service General Hospital, Taiwan
Award ID: TSGH-C106-013
Award Recipient
:
Shia-Ping Lee
Funded by: Tri-Service General Hospital, Taiwan
Award ID: TSGH-C106-013
Award Recipient
:
Chen-Yu Kao
Funded by: The Ministry of National Defense, Taiwan
Award ID: MAB-105-139
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3075-2118
Chien-Ping Chiang
Funded by: The Ministry of National Defense, Taiwan
Award ID: MAB-105-140
Award Recipient
:
Shia-Ping Lee
Funded by: The Ministry of National Defense, Taiwan
Award ID: MAB-106-070
Award Recipient
:
Jehng-Kang Wang
Funded by: funder-id http://dx.doi.org/10.13039/100000054, National Cancer Institute;
Award ID: CA123223
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6391-2571
Chen-Yong Lin
Funded by: funder-id http://dx.doi.org/10.13039/100000054, National Cancer Institute;
Award ID: CA123223
Award Recipient
:
Michael D. Johnson
This study was supported by National Cancer Institute (NCI) Grant RO1 CA 123223 (to
M.D. Johnson and C.-Y. Lin), Grant (MAB106-070) from the Ministry of National Defense,
Taiwan (to J.-K. Wang), Grant (TSGH-C106-013) from the Tri-Service General Hospital,
Taiwan (to S.-P. Lee and C.-Y. Kao), Grant (MAB-105-139) from the Ministry of National
Defense, Taiwan (to C.-P. Chiang), and Grant (MAB-105-140) from the Ministry of National
Defense, Taiwan (to S.-P. Lee). We also acknowledge the assistance provided by the
Histopathology and Tissue Shared Resource and the Microscopy and Imaging Shared Resource
which are supported in part by the Lombardi Comprehensive Cancer Center support grant
(NIH/NCI grant P30-CA051008).
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzyme Precursors
Subject:
Zymogens
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Integumentary System
Subject:
Skin
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Integumentary System
Subject:
Skin
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Keratinocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Keratinocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Keratinocytes
Subject:
Research and Analysis Methods
Subject:
Specimen Preparation and Treatment
Subject:
Staining
Subject:
Cell Staining
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Proteases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Proteases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Tissue Distribution
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacokinetics
Subject:
Tissue Distribution
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Proteases
Subject:
Serine Proteases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Proteases
Subject:
Serine Proteases
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Subcellular Localization
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