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Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B
Greta Acerbi ,
Ilaria Montali ,
Gennaro Domenico Ferrigno ,
Valeria Barili ,
Simona Schivazappa ,
Arianna Alfieri ,
Diletta Laccabue ,
Alessandro Loglio ,
Marta Borghi ,
Marco Massari ,
Marzia Rossi ,
Andrea Vecchi ,
Amalia Penna ,
Carolina Boni ,
Gabriele Missale ,
Pietro Lampertico ,
Daniele Del Rio ,
Carlo Ferrari ,
Paola Fisicaro
April 2021
April 2021
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Abstract
<p class="first" id="d302942e247">In chronic HBV infection, mitochondrial functions
and proteostasis are dysregulated
in exhausted HBV-specific CD8 T cells. To better characterise the potential involvement
of deregulated protein degradation mechanisms in T cell exhaustion, we analysed lysosome-mediated
autophagy in HBV-specific CD8 T cells. Bioactive compounds able to simultaneously
target both mitochondrial functions and proteostasis were tested to identify optimal
combination strategies to reconstitute efficient antiviral CD8 T cell responses in
patients with chronic HBV infection.
</p>
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