Immunogenicity and Biodistribution of Anthrax DNA Vaccine Delivered by Intradermal Electroporation.

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Abstract

Anthrax is a lethal bacterial disease caused by gram-positive bacterium Bacillus anthracis and vaccination is a desirable method to prevent anthrax infections. In the present study, DNA vaccine encoding a protective antigen of Bacillus anthracis was prepared and we investigated the influence of DNA electrotransfer in the skin on the induced immune response and biodistribution.

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Journal

Journal ID (iso-abbrev): Curr Drug Deliv

Title: Current drug delivery

Publisher: Bentham Science Publishers Ltd.

ISSN (Electronic): 1875-5704

ISSN (Print): 1567-2018

Publication date (Electronic): 2020

Volume: 17

Issue: 5

Affiliations

[1 ] ABION Inc., R&D Center, Seoul, Korea.

[2 ] The 4th R & D Institute Directorate, Agency for Defense Development, Daejon, Korea.

[3 ] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.

[4 ] Bio-MAX/N-Bio, Seoul National University, Seoul, Korea.

Article

Publisher Item ID: CDD-EPUB-105804

DOI: 10.2174/1567201817666200414144550

PubMed ID: 32286944

SO-VID: d54705b3-7b9a-4f71-9305-e84a64d01a58

History

Keywords: Anthrax,DNA vaccine,biodistribution,electroporation,immune response,skin delivery.

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Keywords: Anthrax, DNA vaccine, biodistribution, electroporation, immune response, skin delivery.

Immunogenicity and Biodistribution of Anthrax DNA Vaccine Delivered by Intradermal Electroporation.

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Malaria vaccine development

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