Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The mechanistic target of rapamycin (mTOR) pathway is pivotal for cell growth. Regulatory associated protein of mTOR complex I (Raptor) is a unique component of this pro-growth complex. The present study tested whether variation across the raptor gene (RPTOR) is associated with overweight and hypertension.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Am J Hypertens

Title: American journal of hypertension

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1941-7225

ISSN (Print): 0895-7061

Publication date (Electronic): Apr 2015

Volume: 28

Issue: 4

Affiliations

[1 ] brian.morris@sydney.edu.au.

[2 ] University of Oklahoma Health Sciences Center, Reynolds Department of Geriatric Medicine, Oklahoma City, Oklahoma;

[3 ] Honolulu Heart Program (HHP)/Honolulu-Asia Aging Study (HAAS), Department of Research, Kuakini Medical Center, Honolulu, Hawaii;

[4 ] Honolulu Heart Program (HHP)/Honolulu-Asia Aging Study (HAAS), Department of Research, Kuakini Medical Center, Honolulu, Hawaii; Public Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii;

[5 ] Honolulu Heart Program (HHP)/Honolulu-Asia Aging Study (HAAS), Department of Research, Kuakini Medical Center, Honolulu, Hawaii; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii;

[6 ] Honolulu Heart Program (HHP)/Honolulu-Asia Aging Study (HAAS), Department of Research, Kuakini Medical Center, Honolulu, Hawaii; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii; Department of Human Welfare, Okinawa International University, Ginowan, Okinawa, Japan;

[7 ] Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii.

Article

Publisher Item ID: hpu188

DOI: 10.1093/ajh/hpu188

PMC ID: 4425837

PubMed ID: 25249372

SO-VID: d5048808-ebc2-4f49-aa12-154985fdfde2

History

Keywords: blood pressure,body weight,essential hypertension,genetic association analysis,hypertension,isolated systolic hypertension,mechanistic target of rapamycin (mTOR),raptor gene (RPTOR),recursive partitioning analysis.

Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry.

Read this article at

Abstract

Related collections

Technology, Mind, and Behavior

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 300

Cited by 5