Non-invasive glucose prediction and classification using NIR technology with machine learning

Abstract

In this paper, a dual wavelength short near-infrared system is described for the detection of glucose levels. The system aims to improve the accuracy of blood glucose detection in a cost-effective and non-invasive way. The accuracy of the method is evaluated using real-time samples collected with the reference finger prick glucose device. A feed forward neural network (FFNN) regression method is employed to predict glucose levels based on the input data obtained from NIR technology. The system calculates glucose evaluation metrics and performs Surveillance error grid (SEG) analysis. The coefficient of determination $R^2$ and mean absolute error are observed 0.99 and 2.49 mg/dl, respectively. Additionally, the system determines the root mean square error (RMSE) as 3.02 mg/dl. It also shows that the mean absolute percentage error (MAPE) is 1.94% and mean squared error (MSE) is 9.16 ${(mg/dl)}^2$ for FFNN. The SEG analysis shows that the glucose values measured by the system fall within the clinically acceptable range when compared to the reference method. Finally, the system uses the multi-class classification method of the multilayer perceptron (MLP) and K-nearest neighbors (KNN) classifier to classify glucose levels with an accuracy of 99%.