Heritability of Psychological Traits and Developmental Milestones in Infancy : A Systematic Review and Meta-analysis

Abstract

This systematic review and meta-analysis investigates the correlation of genetic and shared and nonshared environment factors with infant developmental milestones.

Key Points

Question

What are the overall genetic and shared and nonshared environment estimates for psychological traits and developmental milestones in infancy?

Findings

In this systematic review and meta-analysis of 139 infant twin studies involving almost 80 000 twins globally, moderate to high genetic and shared and nonshared environment estimates were found across a range of important psychological traits and developmental milestones in infancy.

Meaning

These results offer insight into the degree to which genes and environments estimate outcomes in key domains of infant functioning and suggest highly heritable traits that may be particularly suitable candidates for gene discovery.

Abstract

Importance

Although infancy is the most rapid period of postnatal growth and development, factors associated with variation in infant traits are not well understood.

Objective

To synthesize the large twin study literature partitioning phenotypic variance in psychological traits and developmental milestones in infancy into estimates of heritability and shared and nonshared environment.

Data Sources

PubMed, PsycINFO, and references of included publications were searched up to February 11, 2021.

Study Selection

Peer-reviewed publications using the classical twin design to study psychological traits and developmental milestones from birth to 2 years old were included.

Data Extraction and Synthesis

Data were extracted in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and categorized using the International Classification of Functioning, Disability and Health: Children and Youth Version . Data were pooled in 3-level random effects models, incorporating within-cohort variance in outcome measurement and between-cohort variance. Data were analyzed from March 2021 through September 2021.

Main Outcomes and Measures

The primary outcomes were monozygotic and dizygotic twin correlations. These were used to calculate genetic and shared and nonshared environment estimates.

Results

Among 139 publications that were systematically retrieved, data were available on 79 044 twin pairs (31 053 monozygotic and 47 991 dizygotic pairs), 52 independent samples, and 21 countries. Meta-analyses were conducted on psychological traits and developmental milestones from 106 publications organized into 10 categories of functioning, disability, and health. Moderate to high genetic estimates for 8 categories were found, the highest of which was psychomotor functions (pooled h ² , 0.59; 95% CI, 0.25-0.79; P < .001). Several categories of traits had substantial shared environment estimates, the highest being mental functions of language (pooled c ² , 0.59; 95% CI, 0.24-0.86; P = .001). All examined categories of traits had moderate or high nonshared environment estimates, the highest of which were emotional functions (pooled e ² , 0.42; 95% CI, 0.33-0.50; P < .001) and family relationships (pooled e ² , 0.42; 95% CI, 0.30-0.55; P < .001).

Conclusions and Relevance

These findings may be an important source of information to guide future gene discovery research, public perspectives on nature and nurture, and clinical insights into the degree to which family history and environments may estimate major domains of infant functioning, disability, and health in psychological traits and developmental milestones.