Coastal erosion and its impacts on the involved communities is a topic of great scientific interest that also reflects the need for modern as well as cost and time-effective methodologies to be integrated into or even to substitute traditional investigation methods. The present study is based on an integrated approach that involves the use of data derived from UAV (Unmanned Aerial Vehicle) surveys. The study illustrates the long- to short-term shoreline evolution of the Molise coast (southern Italy) and then focuses on two selected beach stretches (Petacciato and Campomarino beaches), for which annual UAV surveys were performed from 2019 to 2021, to assess their most recent shoreline and morpho-topographical changes and related effects on their coastal vulnerability. UAV data were processed using the Structure from Motion (SfM) image processing tool. Along the beach profiles derived from the produced DEMs, the coastal vulnerability of the selected beach stretches was evaluated by using the Coastal Vulnerability Assessment (CVA) approach. The results obtained highlight some significant worsening of CVA indexes from 2019 to 2021, especially for the Campomarino beach, confirming the importance of the periodic updating of previous data. In conclusion, the easy use of the UAV technology and the good quality of the derived data make it an excellent approach for integration into traditional methodologies for the assessment of short-term shoreline and beach changes as well as for monitoring coastal vulnerability.