5
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Depresión como entidad médico-psiquiátrica Translated title: Depression as a Medical-Psychiatric Entity

      other

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Introducción: La depresión como entidad médico-psiquiátrica obliga al clínico a tomar múltiples herramientas para obtener la etiología exacta, que le permita dilucidar entre los acontecimientos intrapsíquicos y el desequilibrio en la homeostasis del individuo. Método: Se enumeran diferentes entidades médicas que cursan con sintomatología depresiva y algunos enfoques para su tratamiento farmacológico. Conclusión: En un futuro próximo, la psiquiatría podría guiarse mediante pruebas clínicas especializadas, al igual que cualquier otra especialidad y diagnosticar a partir de datos clínicos y pruebas de laboratorio, para aumentar de esta forma la efi cacia terapéutica.

          Translated abstract

          Introduction: Depression as a medical-psychiatric entity forces the clinician to use multiple tools in order to arrive to the precise etiology that will allow him to discern between intrapsychic events and lost homeostasis. Method: Different medical entities that present with depressive symptomatology and some approaches to pharmacological treatment are listed. Conclusion: In the near future, psychiatry may be guided with the help of specialized clinical tests same as in any other specialty, and diagnose with the use of both clinical and laboratory data thus enhancing therapeutic effi ciency.

          Related collections

          Most cited references51

          • Record: found
          • Abstract: not found
          • Article: not found

          Neurobiology of Depression

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.

            Theories of human behavior from Plato to Freud have repeatedly emphasized links between emotion and reason, a relationship now commonly attributed to pathways connecting phylogenetically "old" and "new" brain regions. Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state. Regions of concordant functional change accompanying provocation of transient sadness in healthy volunteers and resolution of chronic dysphoric symptoms in depressed patients were examined with two positron emission tomography techniques: [15O]water and [18F]fluorodeoxyglucose, respectively. With sadness, increases in limbic-paralimbic blood flow (subgenual cingulate, anterior insula) and decreases in neocortical regions (right dorsolateral prefrontal, inferior parietal) were identified. With recovery from depression, the reverse pattern, involving the same regions, was seen--limbic metabolic decreases and neocortical increases. A significant inverse correlation between subgenual cingulate and right dorsolateral prefrontal activity was also demonstrated in both conditions. Reciprocal changes involving subgenual cingulate and right prefrontal cortex occur with both transient and chronic changes in negative mood. The presence and maintenance of functional reciprocity between these regions with shifts in mood in either direction suggests that these regional interactions are obligatory and probably mediate the well-recognized relationships between mood and attention seen in both normal and pathological conditions. The bidirectional nature of this limbic-cortical reciprocity provides additional evidence of potential mechanisms mediating cognitive ("top-down"), pharmacological (mixed), and surgical ("bottom-up") treatments of mood disorders such as depression.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders.

              The relative contribution of genetic and environmental factors to the development of the major psychiatric disorders has long been debated. Recently, considerable attention has been given to the observations that adverse experiences early in life predispose individuals to the development of affective and anxiety disorders in adulthood. Corticotropin-releasing factor (CRF) is the central coordinator of the endocrinologic, autonomic, immunologic, and behavioral stress responses. When centrally administered, CRF produces many physiologic and behavioral changes reminiscent of both acute stress and depression. Moreover, CRF has also been implicated in the pathogenesis of a variety of anxiety disorders, mainly through CRF neurocircuits connecting the amygdala and the locus ceruleus. Clinical studies have provided convincing evidence for central CRF hypersecretion in depression, and, to a lesser extent, in some anxiety disorders. Evidence mainly from preclinical studies suggests that stress early in life results in persistent central CRF hyperactivity and increased stress reactivity in adulthood. Thus, genetic disposition coupled with early stress in critical phases of development may result in a phenotype that is neurobiologically vulnerable to stress and may lower an individual's threshold for developing depression and anxiety upon further stress exposure. This pathophysiologic model may provide novel approaches to the prevention and treatment of psychopathology associated with stress early in life.
                Bookmark

                Author and article information

                Journal
                rcp
                Revista Colombiana de Psiquiatría
                rev.colomb.psiquiatr.
                Asociacion Colombiana de Psiquiatria. (Bogotá, Distrito Capital, Colombia )
                0034-7450
                June 2008
                : 37
                : 2
                : 220-235
                Affiliations
                [01] orgnameColegio Venezolano de Neuropsicofarmacología
                Article
                S0034-74502008000200007 S0034-7450(08)03700207
                d36840d5-0f25-4c2f-9782-8b119d97b7c4

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 28 September 2007
                : 18 February 2008
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 59, Pages: 16
                Product

                SciELO Colombia

                Self URI: Texto completo solamente en formato PDF (ES)
                Categories
                Articulo de Revisión

                antidepressive agents,pruebas de laboratorio,agentes antidepresivos,depresión,laboratory techniques and procedures,Depression

                Comments

                Comment on this article