Anti-contactin-associated protein-like 2 antibody autoimmune encephalitis with rapidly progressive parkinsonism: a case report and literature review.

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Abstract

Anti-contactin-associated protein-like 2 (CASPR2) antibody encephalitis is a rare autoimmune encephalitis (AE) that often presents with epilepsy, cognitive dysfunction, peripheral neuropathy, autonomic nerve damage, and ataxia. Parkinsonism is often observed in neurodegenerative diseases but progresses slowly, and rapidly progressive parkinsonism is rare. Given that it is a curable parkinsonism, identifying and providing early immunotherapy is crucial.

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Author and article information

Journal

Journal ID (iso-abbrev): Acta Neurol Belg

Title: Acta neurologica Belgica

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 2240-2993

ISSN (Print): 0300-9009

Publication date (Electronic): Dec 2023

Volume: 123

Issue: 6

Affiliations

[1 ] Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, 610072, China. 1005476612@qq.com.

[2 ] Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, 610072, China. 1005476612@qq.com.

[3 ] Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, No.33, 2Nd Road, Furong AvenueWenjiang District, Chengdu, 611731, Sichuan Province, China. 1005476612@qq.com.

[4 ] Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, 610072, China.

[5 ] Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, 610072, China.

[6 ] Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.

[7 ] Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, 610072, China. 1458935803@qq.com.

[8 ] Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, 610072, China. 1458935803@qq.com.

[9 ] Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, No.33, 2Nd Road, Furong AvenueWenjiang District, Chengdu, 611731, Sichuan Province, China. 1458935803@qq.com.

Article

Publisher Item ID: 10.1007/s13760-022-02124-7

DOI: 10.1007/s13760-022-02124-7

PubMed ID: 36273369

SO-VID: d30982e9-3b9e-42f7-acc9-434b4507aa9c

History

Keywords: Anti-contactin-associated protein 2,Voltage-gated potassium,Parkinsonism,Channel complex,Autoimmune encephalitis,Antibody titers

Data availability:

Keywords: Anti-contactin-associated protein 2, Voltage-gated potassium, Parkinsonism, Channel complex, Autoimmune encephalitis, Antibody titers

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