- Record: found
- Abstract: not found
- Article: not found
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d6364480e79">Identifying and validating molecular targets of
interventions that extend the human
health span and lifespan has been difficult, as most clinical biomarkers are not sufficiently
representative of the fundamental mechanisms of ageing to serve as their indicators.
In a recent breakthrough, biomarkers of ageing based on DNA methylation data have
enabled accurate age estimates for any tissue across the entire life course. These
'epigenetic clocks' link developmental and maintenance processes to biological ageing,
giving rise to a unified theory of life course. Epigenetic biomarkers may help to
address long-standing questions in many fields, including the central question: why
do we age?
</p>