Prognostic Value of Combined Detection of Serum IL6, YKL-40, and C-reactive Protein in Patients with Unresectable Pancreatic Cancer.

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Abstract

IL6 and YKL-40 (also known as chitinase 3-like 1 protein, CHI3L1) are produced by pancreatic cancer cells and macrophages and activate inflammation. C-reactive protein (CRP) is synthesized mainly in hepatic cells and primarily stimulated by IL6. The aim of this study was to determine the prognostic value of combined detection of serum IL6, YKL-40, and CRP in patients with pancreatic cancer receiving palliative chemotherapy.

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Journal

Journal ID (iso-abbrev): Cancer Epidemiol Biomarkers Prev

Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Publisher: American Association for Cancer Research (AACR)

ISSN (Electronic): 1538-7755

ISSN (Print): 1055-9965

Publication date (Electronic): January 2020

Volume: 29

Issue: 1

Affiliations

[1 ] Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Inna.Chen@regionh.dk.

[2 ] Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

[3 ] Unit of Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.

[4 ] Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

[5 ] Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

[6 ] Department of Oncology, Odense University Hospital, Odense, Denmark.

[7 ] Department of Oncology, North Zealand University Hospital, Hillerød, Denmark.

[8 ] Department of Oncology, Zealand University Hospital, Næstved, Denmark.

[9 ] Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.

[10 ] Department of Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Article

Publisher Item ID: 1055-9965.EPI-19-0672

DOI: 10.1158/1055-9965.EPI-19-0672

PubMed ID: 31685562

SO-VID: d29773f8-501a-4729-9da4-8f6977f319d0

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