Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.

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Abstract

It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.

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Journal

Journal ID (iso-abbrev): Nat Rev Cancer

Title: Nature reviews. Cancer

Publisher: Springer Science and Business Media LLC

ISSN: 1474-175X

ISSN (Print): 1474-175X

Publication date (Electronic): Apr 2007

Volume: 7

Issue: 4

Affiliations

[1 ] Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Japan.

Article

Publisher Item ID: nrc2111

DOI: 10.1038/nrc2111

PubMed ID: 17384582

SO-VID: d22f5a4f-0741-4102-838e-91c1b690af22

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