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      Effect of COVID‐19 inpatients with cognitive decline on discharge after the quarantine period: A retrospective cohort study

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          Abstract

          Background

          A new SARS‐CoV‐2 variant, Omicron, was reported on November 14, 2021, and it altered the COVID‐19 epidemic with a different peak timing by region in Japan. Residents in the Hiroshima prefecture, especially the vulnerable elderly, were threatened by this wave in advance of many other prefectures. We evaluated the effect of cognitive decline on discharge extension after the quarantine period.

          Methods

          Participants of this retrospective cohort study were patients who were admitted to the care unit for COVID‐19 treatment at Hiroshima University Hospital between January 1, 2022, and March 1, 2022 (60 days). Our primary outcome was the extended length of stay (LOS) in the hospital after the quarantine period (10 days after onset). A negative binomial regression analysis was performed to assess the extended LOS of patients with cognitive decline, adjusting for age classification, gender, and severity of COVID‐19.

          Results

          The total number of participants was 74. Per the level of cognitive function, there were 56 independent participants, 5 mild declines, and 13 severe declines. For the negative binomial regression analysis, the exponentiated coefficient of mild cognitive decline was 3.05 (95% confidential interval [CI]: 1.43–6.49) and that of severe cognitive decline was 1.95 (95% CI: 1.09–3.53).

          Conclusions

          Mild cognitive decline and severe cognitive decline elevated the risk of extended LOS after COVID‐19 patients finished the quarantine period.

          Abstract

          A new SARS‐CoV‐2 variant, Omicron, was reported on November 14, 2021, and it altered the COVID‐19 epidemic with a different peak timing by region in Japan. Residents in Hiroshima prefecture, especially vulnerable elderly, were threatend by this wave in advance of many other prefectures. We showed that mild and severe cognitive decline elevated the risk of discharge extension on the day after COVID‐19 patients finished the quarantine period.

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          Most cited references22

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          Rehospitalizations among patients in the Medicare fee-for-service program.

          Reducing rates of rehospitalization has attracted attention from policymakers as a way to improve quality of care and reduce costs. However, we have limited information on the frequency and patterns of rehospitalization in the United States to aid in planning the necessary changes. We analyzed Medicare claims data from 2003-2004 to describe the patterns of rehospitalization and the relation of rehospitalization to demographic characteristics of the patients and to characteristics of the hospitals. Almost one fifth (19.6%) of the 11,855,702 Medicare beneficiaries who had been discharged from a hospital were rehospitalized within 30 days, and 34.0% were rehospitalized within 90 days; 67.1% [corrected] of patients who had been discharged with medical conditions and 51.5% of those who had been discharged after surgical procedures were rehospitalized or died within the first year after discharge. In the case of 50.2% [corrected] of the patients who were rehospitalized within 30 days after a medical discharge to the community, there was no bill for a visit to a physician's office between the time of discharge and rehospitalization. Among patients who were rehospitalized within 30 days after a surgical discharge, 70.5% were rehospitalized for a medical condition. We estimate that about 10% of rehospitalizations were likely to have been planned. The average stay of rehospitalized patients was 0.6 day longer than that of patients in the same diagnosis-related group whose most recent hospitalization had been at least 6 months previously. We estimate that the cost to Medicare of unplanned rehospitalizations in 2004 was $17.4 billion. Rehospitalizations among Medicare beneficiaries are prevalent and costly. 2009 Massachusetts Medical Society
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            Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis

            A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis. We found that the males had significantly higher disease severity (RR: 1.20, 95% CI: 1.13-1.27, P <0.001) and more prognostic endpoints. Older age was found to be significantly associated with the disease severity and six prognostic endpoints. Chronic kidney disease contributed mostly for death (RR: 7.10, 95% CI: 3.14-16.02), chronic obstructive pulmonary disease (COPD) for disease severity (RR: 4.20, 95% CI: 2.82-6.25), admission to intensive care unit (ICU) (RR: 5.61, 95% CI: 2.68-11.76), the composite endpoint (RR: 8.52, 95% CI: 4.36-16.65,), invasive ventilation (RR: 6.53, 95% CI: 2.70-15.84), and disease progression (RR: 7.48, 95% CI: 1.60-35.05), cerebrovascular disease for acute respiratory distress syndrome (ARDS) (RR: 3.15, 95% CI: 1.23-8.04), coronary heart disease for cardiac abnormality (RR: 5.37, 95% CI: 1.74-16.54). Our study highlighted that the male gender, older age and comorbidities owned strong epidemiological evidence of associations with the severity and prognosis of COVID-19.
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              Clinical epidemiology of hospitalized patients with COVID-19 in Japan: Report of the COVID-19 REGISTRY JAPAN

              Abstract Background There is limited understanding of the characteristics of coronavirus disease 2019 (COVID-19) patients requiring hospitalization in Japan. Methods This study included 2638 cases enrolled from 227 health care facilities that participated in the COVID-19 Registry Japan (COVIREGI-JP). The inclusion criteria for enrollment of a case in COVIREGI-JP are both (1) a positive SARS-CoV-2 test and (2) inpatient treatment at a health care facility. Results The median age of hospitalized patients with COVID-19 was 56 years (interquartile range [IQR]: 40-71). More than half of the cases were male (58.9%, 1542/2619). Nearly 60% of the cases had close contact to confirmed or suspected cases of COVID-19. The median duration of symptoms before admission was 7 days (IQR: 4-10). The most common comorbidities were hypertension (15%, 396/2638) and diabetes without complications (14.2%, 374/2638). The number of non-severe cases (68.2%, n=1798) was twice the number of severe cases (31.8%, n=840) at admission. The respiratory support during hospitalization includes those who received no oxygen support (61.6%, 1623/2636), followed by those who received supplemental oxygen (29.9%, 788/2636), and IMV/ECMO (mechanical ventilation or extracorporeal membrane oxygenation) (8.5%, 225/2636). Overall, 66.9% (1762/2634) of patients were discharged home, while 7.5% (197/2634) died. Conclusions We identified the clinical epidemiological features of COVID-19 in hospitalized patients in Japan. When compared with existing inpatient studies in other countries, these results demonstrated less comorbidities and a trend towards lower mortality.
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                Author and article information

                Contributors
                yoshida.shuhei.0810@gmail.com
                Journal
                J Gen Fam Med
                J Gen Fam Med
                10.1002/(ISSN)2189-7948
                JGF2
                Journal of General and Family Medicine
                John Wiley and Sons Inc. (Hoboken )
                2189-6577
                2189-7948
                02 September 2022
                02 September 2022
                : 10.1002/jgf2.577
                Affiliations
                [ 1 ] Department of Community‐Based Medical System, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima‐ken Japan
                [ 2 ] Department of General Internal Medicine Hiroshima University Hospital Hiroshima‐ken Japan
                [ 3 ] Department of Infectious Diseases Hiroshima University Hospital Hiroshima‐ken Japan
                Author notes
                [*] [* ] Correspondence

                Shuhei Yoshida, MD, PhD, Department of General Internal Medicine, Department of Community‐Based Medical System, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1‐2‐3 Kasumi, Minami‐ku, Hiroshima‐shi, Hiroshima‐ken 734‐8551, Japan.

                Email: yoshida.shuhei.0810@ 123456gmail.com

                Author information
                https://orcid.org/0000-0002-6747-1857
                https://orcid.org/0000-0002-1352-3738
                Article
                JGF2577 JGF2-2022-0052.R2
                10.1002/jgf2.577
                9537993
                d21eddd3-b024-4a8a-8821-c3487d5bba8c
                © 2022 The Authors. Journal of General and Family Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Primary Care Association.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 16 August 2022
                : 02 April 2022
                : 18 August 2022
                Page count
                Figures: 3, Tables: 3, Pages: 7, Words: 4255
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
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                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.0 mode:remove_FC converted:07.10.2022

                quarantine period,cognitive decline,covid‐19,omicron variant

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