G protein‐coupled receptor 39 (GPR39) is a transmembrane zinc receptor with two splice variants, which belongs to the G‐protein‐coupled receptor growth hormone‐releasing peptide family. Its expression is induced by zinc, which activates GPR39, and its activation mediates cell proliferation, ion homeostasis, and anti‐inflammatory, antioxidant, and other pathophysiological effects via different signaling pathways.
The article reviews the latest literature in this field. In particular, the role of GPR39 in nervous system is discussed.
GPR39 can be a promising target in neurological diseases for targeted therapy, which will help doctors overcome the associated problems.
The expression of G protein‐coupled receptor 39 (GPR39) is induced by zinc, which activates GPR39 and later mediates cell proliferation, ion homeostasis maintenance, anti‐inflammatory, antioxidant, and other pathophysiological effects through different signaling pathways. It plays an important neuroprotective role in neurodegeneration, neuroelectrophysiology, and neurovascular homeostasis.