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      HP1: a functionally multifaceted protein.

      1 ,
      Current opinion in genetics & development
      Elsevier BV

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          Abstract

          HP1 (heterochromatin protein 1) is a nonhistone chromosomal protein first discovered in Drosophila melanogaster because of its association with heterochromatin. Numerous studies have shown that such a protein plays a role in heterochromatin formation and gene silencing in many organisms, including fungi and animals. Cytogenetic and molecular studies, performed in Drosophila and other organisms, have revealed that HP1 associates with heterochromatin, telomeres and multiple euchromatic sites. There is increasing evidence that the different locations of HP1 are related to multiple different functions. In fact, recent work has shown that HP1 has a role not only in heterochromatin formation and gene silencing, but also in telomere stability and in positive regulation of gene expression.

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          Author and article information

          Journal
          Curr Opin Genet Dev
          Current opinion in genetics & development
          Elsevier BV
          0959-437X
          0959-437X
          Apr 2008
          : 18
          : 2
          Affiliations
          [1 ] Istituto Pasteur, Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia molecolare, Università La Sapienza, 00185 Roma, Italy.
          Article
          S0959-437X(08)00013-0
          10.1016/j.gde.2008.01.009
          18329871
          d1bbafde-1b6b-46e6-a736-a839ceee655a
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