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The decision to enter mitosis
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Abstract
The phosphotyrosine content of the cdc2 protein kinases, the catalytic component of
maturation-promoting factor (MPF), is an important parameter of mitotic regulation
in a variety of organisms. Recent studies have shed considerable light on how the
cdc2-specific tyrosine kinase (wee1) and its competing phosphatase (cdc25) are regulated
during the cell cycle. A goal for the future will be to obtain a comprehensive picture
of how the wee1-cdc25 regulatory system collaborates with other steps in mitotic activation
to ensure that cell division occurs at the appropriate time during the cell cycle.