MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes.

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Abstract

Chronic skin inflammation in atopic dermatitis (AD) is associated with elevated expression of proinflammatory genes and activation of innate immune responses in keratinocytes. microRNAs (miRNAs) are short, single-stranded RNA molecules that silence genes via the degradation of target mRNAs or inhibition of translation.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Allergy Clin. Immunol.

Title: The Journal of allergy and clinical immunology

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Oct 2014

Volume: 134

Issue: 4

Affiliations

[1 ] Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address: ana.rebane@ut.ee.

[2 ] Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland; Institute of Molecular and Cellular Biology, University of Tartu, Tartu, Estonia.

[3 ] Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

[4 ] Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland.

[5 ] Transgenic Technology Core Laboratory, University of Tartu, Tartu, Estonia.

[6 ] Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

[7 ] Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary; Dermatological Research Group of the Hungarian Academy of Sciences, Szeged, Hungary.

[8 ] Department of Pathology, Tartu University Hospital, Tartu, Estonia.

[9 ] Department of Dermatology and Venereology, University of Tartu, Tartu, Estonia; Dermatology Clinic, Tartu University Hospital, Tartu, Estonia.

[10 ] Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université de Strasbourg, Illkirch, France.

[11 ] Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, Calif.

Article

Publisher Item ID: S0091-6749(14)00735-0

DOI: 10.1016/j.jaci.2014.05.022

PubMed ID: 24996260

SO-VID: d04f5e60-aabf-47ea-a21b-037339ebbc8f

History

Keywords: Allergy,atopic eczema,gene therapy,noncoding RNA

Data availability:

Keywords: Allergy, atopic eczema, gene therapy, noncoding RNA

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