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      Comparing body mass index and obesity‐related comorbidities as predictors in hospitalized COVID‐19 patients

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      Clinical Obesity
      Blackwell Publishing Ltd

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          Abstract

          In Tsoulis et al, 1 Table 4 was published with incorrect model numbers in column 1. It should read “Models 1, 2, 3” instead of “Models 4, 5, 6”. Below is the correct Table 4: TABLE 4 Multivariable analyses of hospitalized SARS‐CoV‐2‐infected patients with a BMI ≥25 with BMI and EOSS as categorical predictor variables AKI ICU Admission Mechanical Ventilation Mortality aOR 95% CI p value aOR 95% CI p value aOR 95% CI p value aOR 95% CI p value Model 1 BMI ≥40 0.66 0.27–1.63 .368 0.64 0.30–1.37 .252 0.79 0.34–1.84 .583 2.91 0.60–14.16 .185 BMI 30.00–39.99 0.63 0.36–1.09 .0959 0.99 0.64–1.53 .953 0.92 0.56–1.53 .752 2.15 0.64–7.19 .213 BMI 25.00–29.99 1 (ref) 1 (ref) 1 (ref) 1 (ref) Model 2 EOSS 3/4 6.61 a 3.83–11.40 a <.001 a 17.54 5.10–60.31 <.001 3.10 a 2.01–4.76 a <.001 a 4.40 a 1.65–11.74 a .00312 a EOSS 2 6.61 a 3.83–11.40 a <.001 a 10.86 3.28–36.01 <.001 3.10 a 2.01–4.76 a <.001 a 4.40 a 1.65–11.74 a .00312 a EOSS 0/1 1 (ref) 1 (ref) 1 (ref) 1 (ref) Model 3 BMI ≥40 0.770 0.29–2.03 .600 0.69 0.32–1.52 .357 0.890 0.37–2.13 .795 3.92 0.77–19.91 .100 BMI 30.00–39.99 0.73 0.41–1.32 .297 1.00 0.64–1.57 .994 1.020 0.610–1.72 .933 2.70 0.79–9.26 .115 BMI 25.00–29.99 1 (ref) 1 (ref) 1 (ref) 1 (ref) EOSS 3/4 6.40 a 3.71–11.05 a <.001 a 17.270 5.02–59.38 <.001 3.10 a 2.01–4.78 a <.001 a 5.05 a 1.83–13.90 a .00174 a EOSS 2 6.40 a 3.71–11.05 a <.001 a 10.710 3.23–35.51 <.001 3.10 a 2.01–4.78 a <.001 a 5.05 a 1.83–13.90 a .00174 a EOSS 0/1 1 (ref) 1 (ref) 1 (ref) 1 (ref) Note: Reference groups—Overweight (BMI 25.00–29.99) for WHO Categories of BMI and EOSS stage 0/1 for EOSS stage. Bolded aORs are statistically significant. Abbreviations: AKI, acute kidney injury; aOR, adjusted odds ratio; BMI, body mass index; CI, confidence interval; EOSS, Edmonton Obesity Staging System; ICU, Intensive Care Unit. a EOSS stage is considered as a continuous predictor variable due to zero counts, with the reference group being the stage below each stage examined (i.e. reference group for EOSS stage 3/4 is EOSS stage 2 and reference group for EOSS stage 2 is EOSS stage 0/1). We apologize for this error.

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          Comparing body mass index and obesity‐related comorbidities as predictors in hospitalized COVID ‐19 patients

          Summary The association between body mass index (BMI) and poor COVID‐19 outcomes in patients has been demonstrated across numerous studies. However, obesity‐related comorbidities have also been shown to be associated with poor outcomes. The purpose of this study was to determine whether BMI or obesity‐associated comorbidities contribute to elevated COVID‐19 severity in non‐elderly, hospitalized patients with elevated BMI (≥25 kg/m2). This was a single‐center, retrospective cohort study of 526 hospitalized, non‐elderly adult (aged 18–64) COVID‐19 patients with BMI ≥25 kg/m2 in suburban New York from March 6 to May 11, 2020. The Edmonton Obesity Staging System (EOSS) was used to quantify the severity of obesity‐related comorbidities. EOSS was compared with BMI in multivariable regression analyses to predict COVID‐19 outcomes. We found that higher EOSS scores were associated with poor outcomes after demographic adjustment, unlike BMI. Specifically, patients with increased EOSS scores had increased odds of acute kidney injury (adjusted odds ratio [aOR] = 6.40; 95% CI 3.71–11.05), intensive care unit admission (aOR = 10.71; 95% CI 3.23–35.51), mechanical ventilation (aOR = 3.10; 95% CI 2.01–4.78) and mortality (aOR = 5.05; 95% CI 1.83–13.90). Obesity‐related comorbidity burden as determined by EOSS was a better predictor of poor COVID‐19 outcomes relative to BMI, suggesting that comorbidity burden may be driving risk in those hospitalized with elevated BMI.
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            Author and article information

            Journal
            Clin Obes
            Clin Obes
            10.1111/(ISSN)1758-8111
            COB
            Clinical Obesity
            Blackwell Publishing Ltd (Chichester, UK )
            1758-8103
            1758-8111
            10 November 2022
            December 2022
            10 November 2022
            : 12
            : 6 ( doiID: 10.1111/cob.v12.6 )
            : e12548
            Article
            COB12548
            10.1111/cob.12548
            9877684
            36354347
            cfed7603-a6fb-402d-aea6-2ae5bf71a0cc
            © 2022 World Obesity Federation.

            This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

            History
            : 25 August 2022
            Page count
            Figures: 0, Tables: 1, Pages: 1, Words: 433
            Categories
            Corrigendum
            Corrigendum
            Custom metadata
            2.0
            December 2022
            Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.4 mode:remove_FC converted:26.01.2023

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