Suppression of antigen presentation by IL-10.

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Abstract

Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.

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Journal

Journal ID (iso-abbrev): Curr. Opin. Immunol.

Title: Current opinion in immunology

ISSN (Electronic): 1879-0372

ISSN (Print): 0952-7915

Publication date (Electronic): Jun 2015

Volume: 34

Affiliations

[1 ] Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

[2 ] Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: paul.roche@nih.gov.

Article

Publisher Item ID: S0952-7915(14)00157-5 Mid ID: NIHMS652276

DOI: 10.1016/j.coi.2014.12.009

PMC ID: 4444374

PubMed ID: 25597442

SO-VID: cfebbc82-1f0f-4b2e-9d0e-ccbf6597895a

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