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      Neuropsychologic deficits in schizophrenia: relation to social function and effect of antipsychotic drug treatment.

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          Abstract

          Cognitive impairment is present in the majority of schizophrenic patients, even at the onset of psychosis. It is a relatively stable characteristic in most patients, usually with little progression over the course of illness, but sometimes progresses to severe dementia. The results of studies of the effects of typical neuroleptic drugs on cognitive functioning in schizophrenia are conflicting. Clozapine, which has superior antipsychotic effects compared to typical neuroleptic drugs, has been reported to improve executive function, verbal fluency, attention, and recall memory in two of three studies. Cognitive measures predict work function and overall outcome on clozapine as assessed by the Global Assessment Scale and Quality-of-Life Scale in neuroleptic--resistant schizophrenia. Improvement in cognitive function by clozapine may be a major reason for expanding its currently limited utilization.

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          Author and article information

          Journal
          Neuropsychopharmacology
          Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
          Elsevier BV
          0893-133X
          0893-133X
          Mar 1996
          : 14
          : 3 Suppl
          Affiliations
          [1 ] Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
          Article
          0893133X9500202O
          10.1016/0893-133X(95)00202-O
          8866741
          cfb0d1cc-052c-48ef-9811-04b918213790
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