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      Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

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          Abstract

          A manganese-iron layered double hydroxide serves as a pH-responsive nanoplatform for simultaneous MRI contrast enhancement and drug delivery.

          Abstract

          Stimuli-responsive theranostic platforms are highly desirable for efficient cancer treatment because of their improved specificity and sensitivity. In this work, we report a manganese-iron layered double hydroxide (MnFe-LDH) for the first time and demonstrate that it can serve as a pH-responsive nanoplatform for cancer theranostics. The MnFe-LDH can respond to the acidic microenvironment of solid tumors to release paramagnetic Mn 2+ and Fe 3+ ions, resulting in great enhancement of the T 1 MRI contrast of the tumor area. In addition, the layered structure enables MnFe-LDH to effectively deliver chemotherapeutic drugs in a pH-controlled manner, and therefore it can simultaneously inhibit the growth of solid tumors. We believe that this novel MnFe-LDH with pH-responsive property holds great promise in cancer theranostic applications.

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          Recent advances in the synthesis and application of layered double hydroxide (LDH) nanosheets.

          Qiang Wang, Dermot O'Hare (2012)
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            A molecular imaging primer: modalities, imaging agents, and applications.

            Michelle L James, Sanjiv Gambhir (2012)
            Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecular imaging agents (i.e., small molecules, peptides, aptamers, engineered proteins, and nanoparticles) and cite examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics (therapy combined with diagnostics). A step-by-step guide to answering biological and/or clinical questions using the tools of molecular imaging is also provided. We conclude by discussing the grand challenges of the field, its future directions, and enormous potential for further impacting how we approach research and medicine.
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              Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials.

              Feng Zhao, Ying Zhao, Ying Liu … (2011)
              The interactions of nanoparticles with the soft surfaces of biological systems like cells play key roles in executing their biomedical functions and in toxicity. The discovery or design of new biomedical functions, or the prediction of the toxicological consequences of nanoparticles in vivo, first require knowledge of the interplay processes of the nanoparticles with the target cells. This article focusses on the cellular uptake, location and translocation, and any biological consequences, such as cytotoxicity, of the most widely studied and used nanoparticles, such as carbon-based nanoparticles, metallic nanoparticles, and quantum dots. The relevance of the size and shape, composition, charge, and surface chemistry of the nanoparticles in cells is considered. The intracellular uptake pathways of the nanoparticles and the cellular responses, with potential signaling pathways activated by nanoparticle interactions, are also discussed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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                Author and article information

                Contributors
                Journal
                Journal ID (publisher-id): JMCBDV
                Title: Journal of Materials Chemistry B
                Abbreviated Title: J. Mater. Chem. B
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Print): 2050-750X
                ISSN (Electronic): 2050-7518
                Publication date Created: 2017
                Publication date (Electronic): 2017
                Volume: 5
                Issue: 20
                Pages: 3629-3633
                Affiliations
                [1 ]MOE Key Laboratory for Analytical Science of Food Safety and Biology
                [2 ]College of Biological Science and Engineering
                [3 ]Fuzhou University
                [4 ]Fuzhou 350116
                [5 ]P. R. China
                [6 ]State Key Laboratory of Photocatalysis on Energy and Environment
                [7 ]College of Chemistry
                [8 ]Department of Diagnostic Radiology
                [9 ]Union Hospital
                [10 ]Fujian Medical University
                [11 ]Fuzhou 350001
                [12 ]State Key Laboratory of Physical Chemistry of Solid Surfaces
                [13 ]The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and The Key Laboratory for Chemical Biology of Fujian Province
                [14 ]College of Chemistry and Chemical Engineering
                [15 ]Xiamen University
                [16 ]Xiamen 361005
                Article
                DOI: 10.1039/C7TB00794A
                SO-VID: ced758f2-197d-4fa1-87e5-951be5d523a1
                Copyright © © 2017
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