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      Imputation by feature importance (IBFI): A methodology to envelop machine learning method for imputing missing patterns in time series data

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          Abstract

          A new methodology, imputation by feature importance (IBFI), is studied that can be applied to any machine learning method to efficiently fill in any missing or irregularly sampled data. It applies to data missing completely at random (MCAR), missing not at random (MNAR), and missing at random (MAR). IBFI utilizes the feature importance and iteratively imputes missing values using any base learning algorithm. For this work, IBFI is tested on soil radon gas concentration (SRGC) data. XGBoost is used as the learning algorithm and missing data are simulated using R for different missingness scenarios. IBFI is based on the physically meaningful assumption that SRGC depends upon environmental parameters such as temperature and relative humidity. This assumption leads to a model obtained from the complete multivariate series where the controls are available by taking the attribute of interest as a response variable. IBFI is tested against other frequently used imputation methods, namely mean, median, mode, predictive mean matching (PMM), and hot-deck procedures. The performance of the different imputation methods was assessed using root mean squared error (RMSE), mean squared log error (MSLE), mean absolute percentage error (MAPE), percent bias (PB), and mean squared error (MSE) statistics. The imputation process requires more attention when multiple variables are missing in different samples, resulting in challenges to machine learning methods because some controls are missing. IBFI appears to have an advantage in such circumstances. For testing IBFI, Radon Time Series Data (RTS) has been used and data was collected from 1 st March 2017 to the 11 th of May 2018, including 4 seismic activities that have taken place during the data collection time.

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          Re-epithelialization and immune cell behaviour in an ex vivo human skin model

          A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification. Here, we present a novel wound model based on application of negative pressure and its effects for epidermal regeneration and immune cell behaviour. Importantly, the basement membrane remained intact after blister roof removal and keratinocytes were absent in the wounded area. Upon six days of culture, the wound was covered with one to three-cell thick K14+Ki67+ keratinocyte layers, indicating that proliferation and migration were involved in wound closure. After eight to twelve days, a multi-layered epidermis was formed expressing epidermal differentiation markers (K10, filaggrin, DSG-1, CDSN). Investigations about immune cell-specific manners revealed more T cells in the blister roof epidermis compared to normal epidermis. We identified several cell populations in blister roof epidermis and suction blister fluid that are absent in normal epidermis which correlated with their decrease in the dermis, indicating a dermal efflux upon negative pressure. Together, our model recapitulates the main features of epithelial wound regeneration, and can be applied for testing wound healing therapies and investigating underlying mechanisms.
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            Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls

            Most studies have some missing data. Jonathan Sterne and colleagues describe the appropriate use and reporting of the multiple imputation approach to dealing with them
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              A Test of Missing Completely at Random for Multivariate Data with Missing Values

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original draft
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole: VisualizationRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                13 January 2022
                2022
                : 17
                : 1
                : e0262131
                Affiliations
                [1 ] Department of Computer Engineering, Ankara Yıldırım Beyazıt University, Ayvalı, Keçiören/Ankara, Turkey
                [2 ] Department of Computer Science and Information Technology, University of Azad Jammu and Kashmir, Muzaffarabad, Azad Kashmir, Pakistan
                [3 ] Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
                [4 ] Department of Physics King Abdullah Campus, University of Azad Jammu and Kashmir Muzaffarabad, Azad Kashmir, Pakistan
                Universiti Teknologi Malaysia, MALAYSIA
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-4183-1519
                https://orcid.org/0000-0002-5216-9380
                Article
                PONE-D-21-18941
                10.1371/journal.pone.0262131
                8758196
                35025953
                ce9e599b-3d37-4198-857a-023c6589ee6f

                This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

                History
                : 9 June 2021
                : 17 December 2021
                Page count
                Figures: 7, Tables: 3, Pages: 22
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/501100010221, Higher Education Commision, Pakistan;
                Award ID: grant No: 6453/AJK/NRPU/R&D/HEC/2016
                Award Recipient :
                Muhammad Rafique Higher Education Commision, Pakistan Grant No: 6453/AJK/NRPU/R&D/HEC/2016 under NRPU scheme to principal investigator MR. www.hec.gov.pk The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Physical Sciences
                Chemistry
                Chemical Elements
                Radon
                Computer and Information Sciences
                Artificial Intelligence
                Machine Learning
                Earth Sciences
                Atmospheric Science
                Meteorology
                Humidity
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Forecasting
                Physical Sciences
                Mathematics
                Statistics
                Statistical Methods
                Forecasting
                Physical Sciences
                Mathematics
                Applied Mathematics
                Algorithms
                Machine Learning Algorithms
                Research and Analysis Methods
                Simulation and Modeling
                Algorithms
                Machine Learning Algorithms
                Computer and Information Sciences
                Artificial Intelligence
                Machine Learning
                Machine Learning Algorithms
                Physical Sciences
                Mathematics
                Statistics
                Statistical Data
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Mathematical Functions
                Physical Sciences
                Mathematics
                Applied Mathematics
                Algorithms
                Research and Analysis Methods
                Simulation and Modeling
                Algorithms
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                All relevant data are within the paper and its Supporting Information files.

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