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Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer.
Emmanuelle Charafe-Jauffret
1 ,
Christophe Ginestier ,
Flora Iovino ,
Carole Tarpin ,
Mark Diebel ,
Benjamin Esterni ,
Gilles Houvenaeghel ,
Jean-Marc Extra ,
François Bertucci ,
Jocelyne Jacquemier ,
Luc Xerri ,
Gabriela Dontu ,
Giorgio Stassi ,
Yi Xiao ,
Sanford H Barsky ,
Daniel Birnbaum ,
Patrice Viens ,
Max S Wicha
Jan 01 2010
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Abstract
To examine the role of cancer stem cells (CSC) in mediating metastasis in inflammatory breast cancer (IBC) and the association of these cells with patient outcome in this aggressive type of breast cancer.