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      Prediction of gestational diabetes mellitus in the first trimester: comparison of maternal fetuin-A, N-terminal proatrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels

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          ABSTRACT

          Objective

          We investigated the utility of maternal fetuin-A, N-terminal proatrial natriuretic peptide (pro-ANP), high-sensitivity C-reactive protein (hs-CRP), and fasting glucose levels at 11-14 gestation weeks for predicting pregnancies complicated by gestational diabetes mellitus (GDM).

          Subjects and methods

          This prospective cohort study included 327 low-risk pregnant women who completed antenatal follow-up at a tertiary research hospital between January and April 2014. Maternal blood samples were collected between 11–14 gestational weeks in the first trimester of pregnancy and then stored at –80 °C until further analyses. During follow-up, 29 (8.8%) women developed GDM. The study population was compared 1:2 with age- and body mass index-matched pregnant women who did not develop GDM (n = 59). Fasting plasma glucose (FPG) levels and serum fetuin-A, pro-ANP, and hs-CRP levels were measured using automated immunoassay systems.

          Results

          There was a significant negative correlation between fetuin-A and hs-CRP (CC = –0.21, p = 0.047) and a positive correlation between FPG and hs-CRP (CC = 0.251, p = 0.018). The areas under the receiver operating characteristic curve for diagnosing GDM were 0.337 (p = 0.013), 0.702 (p = 0.002), and 0.738 (p < 0.001) for fetuin-A, hs-CRP, and FPG, respectively. The optimal cut-off values were > 4.65, < 166, and > 88.5 mg/dL for maternal hs-CRP, fetuin-A, and FPG, respectively.

          Conclusion

          Reduced fetuin-A, elevated hs-CRP, and FPG levels in women in the first trimester can be used for the early detection of GDM. Further research is needed before accepting these biomarkers as valid screening tests for GDM.

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          Most cited references42

          • Record: found
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          G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences

          G*Power (Erdfelder, Faul, & Buchner, 1996) was designed as a general stand-alone power analysis program for statistical tests commonly used in social and behavioral research. G*Power 3 is a major extension of, and improvement over, the previous versions. It runs on widely used computer platforms (i.e., Windows XP, Windows Vista, and Mac OS X 10.4) and covers many different statistical tests of the t, F, and chi2 test families. In addition, it includes power analyses for z tests and some exact tests. G*Power 3 provides improved effect size calculators and graphic options, supports both distribution-based and design-based input modes, and offers all types of power analyses in which users might be interested. Like its predecessors, G*Power 3 is free.
            Bookmark
            • Record: found
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            • Article: not found

            World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.

            (2013)
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Index for rating diagnostic tests

                Bookmark

                Author and article information

                Journal
                Arch Endocrinol Metab
                Arch Endocrinol Metab
                aem
                Archives of Endocrinology and Metabolism
                Sociedade Brasileira de Endocrinologia e Metabologia
                2359-3997
                2359-4292
                15 April 2019
                Mar-Apr 2019
                : 63
                : 2
                : 121-127
                Affiliations
                [1 ] orgnameUniversity of Health Sciences orgdiv1Zekai Tahir Burak Health Practice Research Center Ankara Turkey originalUniversity of Health Sciences, Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey
                [2 ] orgnameGazi University Faculty of Medicine orgdiv1Department of Medical Biochemistry Ankara Turkey originalGazi University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey
                Author notes
                Correspondence to: A. Seval Ozgu-Erdinc. University of Health Sciences, Zekai Tahir Burak Health Practice Research Center Talatpasa Bulvari 06230 – Ankara, Turkey sevalerdinc@ 123456gmail.com

                Disclosure: no potential conflict of interest relevant to this article was reported.

                Article
                2359-3997000000126
                10.20945/2359-3997000000126
                10522132
                31038593
                ce24ccf2-3d8d-49f9-b469-6f5cafae06e9

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 17 April 2018
                : 20 February 2019
                Page count
                Figures: 1, Tables: 3, Equations: 0, References: 40, Pages: 7
                Categories
                Original Article

                gestational diabetes,first trimester screening,fetuin-a,n-terminal peptide of proatrial natriuretic peptide,high sensitivity c-reactive protein,fasting plasma glucose

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