Matrix metalloproteinases-9 deficiency impairs liver regeneration through epidermal growth factor receptor signaling in partial hepatectomy mice.

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Abstract

Liver regeneration is a complex process regulated by many complex mechanisms involving cytokines, growth factors, metabolic networks, and so forth. Previous investigations have demonstrated that matrix metalloproteinase-9 (MMP-9) is an essential factor in liver regeneration. The present study aimed to explore the role of MMP-9 in epidermal growth factor receptor (EGFR) signaling and related proliferation signaling factors in a mouse partial hepatectomy (PH) model.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Surg. Res.

Title: The Journal of surgical research

ISSN (Electronic): 1095-8673

ISSN (Print): 0022-4804

Publication date (Electronic): Jul 2015

Volume: 197

Issue: 1

Affiliations

[1 ] Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing, Jiangsu Province, China.

[2 ] Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing, Jiangsu Province, China. Electronic address: lvling@njmu.edu.cn.

[3 ] Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; Key Laboratory of Living Donor Liver Transplantation of Ministry of Public Health, Nanjing, Jiangsu Province, China. Electronic address: liguoqiang@njmu.edu.cn.

Article

Publisher Item ID: S0022-4804(15)00340-6

DOI: 10.1016/j.jss.2015.03.081

PubMed ID: 25956184

SO-VID: cdd52f63-0b4b-4b4a-b2c6-b8cb2d16469d

History

Keywords: Amphiregulin,EGFR,HB-EGF,Liver regeneration,MMP-9

Data availability:

Keywords: Amphiregulin, EGFR, HB-EGF, Liver regeneration, MMP-9

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