Eriks Smagris:
ORCID: https://orcid.org/0000-0002-5311-2685
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Lisa M. Shihanian: Role: Formal analysisRole: InvestigationRole: Validation
Ivory J. Mintah: Role: Formal analysisRole: InvestigationRole: Validation
Parnian Bigdelou: Role: Investigation
Yuliya Livson: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Validation
Heather Brown: Role: Investigation
Niek Verweij: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Charleen Hunt:
ORCID: https://orcid.org/0000-0003-0537-862X
Role: SupervisionRole: Writing – review & editing
Reid O’Brien Johnson: Role: SupervisionRole: Writing – review & editing
Tyler J. Greer:
ORCID: https://orcid.org/0000-0003-0198-1157
Role: Writing – review & editing
Suzanne A. Hartford:
ORCID: https://orcid.org/0000-0001-8816-8585
Role: SupervisionRole: Writing – review & editing
George Hindy: Role: Writing – review & editing
Luanluan Sun: Role: Writing – review & editing
Jonas B. Nielsen:
ORCID: https://orcid.org/0000-0002-6654-2852
Role: Writing – review & editing
Gabor Halasz: Role: Data curationRole: Formal analysis
Luca A. Lotta: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Andrew J. Murphy: Role: ConceptualizationRole: Writing – review & editing
Mark W. Sleeman: Role: ConceptualizationRole: Writing – review & editing
Viktoria Gusarova: Role: ConceptualizationRole: MethodologyRole: Project administrationRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Jiandie Lin: Role: Editor
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Title:
PLOS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
4
March
2024
Publication date Collection:
March
2024
Volume: 20
Issue: 3
Electronic Location Identifier: e1011179
Affiliations
[001]
Regeneron Pharmaceuticals, Tarrytown, New York, Unites States of America
University of Michigan, UNITED STATES
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: All authors are employees and shareholders of Regeneron Pharmaceuticals,
Inc.
Author information
Article
Publisher ID:
PGENETICS-D-23-01107
DOI: 10.1371/journal.pgen.1011179
PMC ID: 10939284
PubMed ID: 38437227
SO-VID: cdcfc0a0-eeb3-43ee-b1a0-27f6722fb95a
Copyright © © 2024 Smagris et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
ORCID: https://orcid.org/0000-0002-5311-2685
Eriks Smagris
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Lisa M. Shihanian
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Ivory J. Mintah
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Parnian Bigdelou
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Yuliya Livson
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Heather Brown
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Niek Verweij
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
ORCID: https://orcid.org/0000-0003-0537-862X
Charleen Hunt
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Reid O'Brien Johnson
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
ORCID: https://orcid.org/0000-0003-0198-1157
Tyler J. Greer
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
ORCID: https://orcid.org/0000-0001-8816-8585
Suzanne A. Hartford
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
George Hindy
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Luanluan Sun
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
ORCID: https://orcid.org/0000-0002-6654-2852
Jonas B. Nielsen
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Gabor Halasz
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Luca A. Lotta
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Andrew J. Murphy
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Mark W. Sleeman
Funded by:
funder-id http://dx.doi.org/10.13039/100009857, Regeneron Pharmaceuticals;
Award Recipient
:
Viktoria Gusarova
All authors are employees of Regeneron Pharmaceuticals and all studies in this manuscript
are financed by Regeneron Pharmaceuticals. Only authors of this manuscript are contributed
to study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Subject:
Research Article
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Research and Analysis Methods
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Animal Studies
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Experimental Organism Systems
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Model Organisms
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Mouse Models
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Research and Analysis Methods
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Model Organisms
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Mouse Models
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Research and Analysis Methods
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Animal Studies
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Experimental Organism Systems
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Animal Models
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Mouse Models
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Fatty Liver
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Biology and Life Sciences
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Bioengineering
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Biotechnology
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Genetic Engineering
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Genetically Modified Organisms
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Genetically Modified Animals
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Engineering and Technology
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Biotechnology
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Genetic Engineering
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Genetically Modified Organisms
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Genetically Modified Animals
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Biology and Life Sciences
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Nutrition
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Medicine and Health Sciences
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Diet
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Medicine and Health Sciences
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Gastroenterology and Hepatology
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Liver Diseases
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Biochemistry
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Lipids
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Biology and Life Sciences
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Gene Expression
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Biology and Life Sciences
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Cell Biology
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Cellular Types
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Animal Cells
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Hepatocytes
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Biology and Life Sciences
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Anatomy
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Liver
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Hepatocytes
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Medicine and Health Sciences
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Liver
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Hepatocytes