For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
47
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      595
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Oxycodone Self-Administration in Female Rats is Enhanced by ∆ 9-tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure

      Preprint
      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Epidemiological evidence suggests that the legalization of cannabis may reduce opioid-related harms. Preclinical evidence of neuropharmacological interactions of endogenous cannabinoid and opioid systems prompts further investigation of cannabinoids as potential therapeutics for the non-medical use of opioids. In these studies female rats, previously trained to self-administer oxycodone (0.15 mg/kg/infusion) intravenously in 6 h sessions, were allowed to self-administer oxycodone after exposure to cannabidiol (CBD) and Δ 9-tetrahydrocannabinol (THC) by vapor inhalation and THC by injection (5.0–20 mg/kg, i.p.). Self-administration was characterized under Progressive Ratio (PR) and Fixed Ratio (FR) 1 schedules of reinforcement in 3 h sessions. THC decreased IVSA of oxycodone in a FR procedure but increased reward seeking in a PR procedure. CBD decreased the IVSA of oxycodone in the FR but not the PR procedure. The results are consistent with an anti-reward effect of CBD but suggest THC acts to increase the reinforcing efficacy of oxycodone in this procedure.

          Related collections

          Most cited references47

          • Record: found
          • Abstract: found
          • Article: not found

          Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy.

          Nicole Richardson, David Roberts (1996)
          Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats. Session parameters adopted for use in our laboratory and the considerations relevant to them are described. The strengths and weaknesses of the PR schedule are also discussed.
          Article 0 comments Cited 262 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Progressive ratio as a measure of reward strength.

            W Hodos (1961)
            Four rats were trained to press a lever on a ratio schedule of reinforcement in which the number of lever presses required on each consecutive run increased by a fixed increment. Both concentration and volume of the reward were varied. Relationships were obtained between reward and deprivation variables and the size of the final completed ratio run.
            Article 0 comments Cited 186 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol

              Douglas Boggs, Jacques Nguyen, Daralyn Morgenson … (2017)
              The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its psychotropic and mind-altering side effects for millennia. There has been growing attention in recent years on its potential therapeutic efficacy as municipalities and legislative bodies in the United States, Canada, and other countries grapple with enacting policy to facilitate the use of cannabis or its constituents for medical purposes. There are >550 chemical compounds and >100 phytocannabinoids isolated from cannabis, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is thought to produce the main psychoactive effects of cannabis, while CBD does not appear to have similar effects. Studies conflict as to whether CBD attenuates or exacerbates the behavioral and cognitive effects of THC. This includes effects of CBD on THC-induced anxiety, psychosis, and cognitive deficits. In this article, we review the available evidence on the pharmacology and behavioral interactions of THC and CBD from preclinical and human studies, particularly with reference to anxiety and psychosis-like symptoms. Both THC and CBD, as well as other cannabinoid molecules, are currently being evaluated for medicinal purposes, separately and in combination. Future cannabis-related policy decisions should include consideration of scientific findings, including the individual and interactive effects of CBD and THC.
              Article 0 comments Cited 89 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): bioRxiv
                Journal ID (publisher-id): BIORXIV
                Title: bioRxiv
                Publisher: Cold Spring Harbor Laboratory
                Publication date (Electronic): 31 October 2023
                Electronic Location Identifier: 2023.10.26.564282
                Affiliations
                [1 ]Department of Psychiatry, University of California, San Diego; La Jolla, CA, USA
                [2 ]Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA
                Author notes
                Address Correspondence to: Dr. Jacques D. Nguyen, One Bear Place, Waco, TX, 76798-7334, jacques_nguyen@ 123456baylor.edu ; Or, Dr. Michael A. Taffe, Department of Psychiatry, 9500 Gilman Drive; University of California, San Diego, La Jolla, CA 92093; USA; mtaffe@ 123456ucsd.edu
                Author information
                http://orcid.org/0000-0003-0397-0582
                http://orcid.org/0000-0002-6336-0164
                http://orcid.org/0000-0001-9827-1738
                Article
                DOI: 10.1101/2023.10.26.564282
                PMC ID: 10634900
                PubMed ID: 37961225
                SO-VID: cdbd1910-6d46-4520-a951-5ff43abfd087
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

                History
                Categories
                Subject: Article

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content595

                See all similar

                Cited by1

                See all cited by

                Most referenced authors429

                See all reference authors