Contributors
Ravindra Jadhav: Role: InvestigationRole: MethodologyRole: Writing – original draft
Ricardo Gallardo-Macias: Role: InvestigationRole: Methodology
Gaurav Kumar: Role: Formal analysisRole: InvestigationRole: Methodology
Samer S. Daher: Role: InvestigationRole: MethodologyRole: Writing – original draft
Amit Kaushik: Role: InvestigationRole: Methodology
Kristina M. Bigelow: Role: InvestigationRole: Methodology
Eric L. Nuermberger: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Gyanu Lamichhane: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Joel S. Freundlich:
ORCID: https://orcid.org/0000-0002-3411-3455
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Alistair K. Brown: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
3
May
2021
Publication date Collection: 2021
Volume: 16
Issue: 5
Electronic Location Identifier: e0249841
Affiliations
[1
]
Department of Pharmacology, Physiology, and Neuroscience, Rutgers University–New Jersey
Medical School, Newark, New Jersey, United States of America
[2
]
Center for Tuberculosis Research and Department of Medicine, Johns Hopkins University,
Baltimore, MD, United States of America
[3
]
Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center
for the Study of Emerging and Re-emerging Pathogens, Rutgers University—New Jersey
Medical School, Newark, New Jersey, United States of America
Newcastle University, UK, UNITED KINGDOM
Author notes
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following
competing interests: the authors declare that a United States patent (US10,695,322)
has been granted, including J.S.F., G.L., and A.K. as inventors, relevant to the carbapenems
disclosed herein. Novel Inhibitors of Bacterial Growth, U.S. Patent 10,695,322, issued
June 30, 2020, Assignees: The Johns Hopkins University (Baltimore, MD), Rutgers, The
State University of New Jersey (New Brunswick, NJ), Inventors: Gyanu Lamichhane (Towson,
MD), Craig A. Townsend (Baltimore, MD), Evan Lloyd (Bunker Hill, WV), Amit Kaushik
(Baltimore, MD), Pankaj Kumar (Baltimore, MD), Joel Freundlich (Princeton, NJ), Shaogang
Li (Newark, NJ), Sean Ekins (Fuquay Varina, NC), Nicole Parrish (Bunker Hilol, WV.
This does not alter our adherence to PLOS ONE policies on sharing data and materials.
[¤]
Current address: R. J.–Piramal Pharma Solutions; R.G.M.–Institute for Therapeutics
Discovery and Development, University of Minnesota, Minneapolis, Minnesota, United
States of America
Author information
Article
Publisher ID:
PONE-D-20-37167
DOI: 10.1371/journal.pone.0249841
PMC ID: 8092647
PubMed ID: 33939697
SO-VID: cd7ca9b2-5c1e-4b3d-9810-c9d052a478a4
Copyright © © 2021 Jadhav et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 25
November
2020
Date
accepted
: 25
March
2021
Page count
Figures: 4,
Tables: 1,
Pages: 11
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000009, Foundation for the National Institutes of Health;
Award ID: R33AI111739
Award Recipient
:
Gyanu Lamichhane
G.L., J.S.F., and E.L.N. acknowledge support from award number R33AI111739 “Development
of oral carbapenem drugs for treatment of drug resistant TB” from the National Institutes
of Health and National Institute of Allergy and Infectious Diseases. The funders had
no role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Actinobacteria
Subject:
Mycobacterium Tuberculosis
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Reactions
Subject:
Organic Reactions
Subject:
Hydrogenation
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Reactions
Subject:
Hydrogenation
Subject:
Research and Analysis Methods
Subject:
Chemical Synthesis
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Animal Models of Disease
Subject:
Animal Models of Infection
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Animal Models of Infection
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacokinetics
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Elements
Subject:
Sodium
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Bicarbonates
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