Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.

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Abstract

Coagulopathy is present at admission in 25% of trauma patients, is associated with shock and a 5-fold increase in mortality. The coagulopathy has recently been associated with systemic activation of the protein C pathway. This study was designed to characterize the thrombotic, coagulant and fibrinolytic derangements of trauma-induced shock.

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Journal

Journal ID (iso-abbrev): J Trauma

Title: The Journal of trauma

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1529-8809

ISSN (Print): 0022-5282

Publication date (Electronic): May 2008

Volume: 64

Issue: 5

Affiliations

[1 ] Department of Surgery, The Royal London Hospital, London, United Kingdom.

Article

Publisher Item ID: 00005373-200805000-00010

DOI: 10.1097/TA.0b013e318169cd3c

PubMed ID: 18469643

SO-VID: ccbbcfab-6c2e-4dbc-8bf9-1d4b1ae1a6e3

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