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      State-of-the-art surgery for sigmoid diverticulitis

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          Abstract

          Background

          In the last two decades, there has been a Copernican revolution in the decision-making for the treatment of Diverticular Disease.

          Purpose

          This article provides a report on the state-of-the-art of surgery for sigmoid diverticulitis.

          Conclusion

          Acute diverticulitis is the most common reason for colonic resection after cancer; in the last decade, the indication for surgical resection has become more and more infrequent also in emergency. Currently, emergency surgery is seldom indicated, mostly for severe abdominal infective complications. Nowadays, uncomplicated diverticulitis is the most frequent presentation of diverticular disease and it is usually approached with a conservative medical treatment. Non-Operative Management may be considered also for complicated diverticulitis with abdominal abscess. At present, there is consensus among experts that the hemodynamic response to the initial fluid resuscitation should guide the emergency surgical approach to patients with severe sepsis or septic shock. In hemodynamically stable patients, a laparoscopic approach is the first choice, and surgeons with advanced laparoscopic skills report advantages in terms of lower postoperative complication rates. At the moment, the so-called Hartmann’s procedure is only indicated in severe generalized peritonitis with metabolic derangement or in severely ill patients. Some authors suggested laparoscopic peritoneal lavage as a bridge to surgery or also as a definitive treatment without colonic resection in selected patients. In case of hemodynamic instability not responding to fluid resuscitation, an initial damage control surgery seems to be more attractive than a Hartmann’s procedure, and it is associated with a high rate of primary anastomosis.

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          Most cited references70

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          Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

          To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012".
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            Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

            Critical Care Medicine, 34(6), 1589-1596
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              Epidemiology, Pathophysiology, and Treatment of Diverticulitis

              Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant morbidity and health care costs. Approximately 20% of patients with incident diverticulitis have at least 1 recurrence. Complications of diverticulitis, such as abdominal sepsis, are less likely to occur with subsequent events. Several risk factors, many of which are modifiable, have been identified including obesity, diet, and physical inactivity. Diet and lifestyle factors could affect risk of diverticulitis through their effects on the intestinal microbiome and inflammation. Preliminary studies have found that the composition and function of the gut microbiome differ between individuals with vs without diverticulitis. Genetic factors, as well as alterations in colonic neuromusculature, can also contribute to the development of diverticulitis. Less-aggressive and more-nuanced treatment strategies have been developed. Two multicenter, randomized trials of patients with uncomplicated diverticulitis found that antibiotics did not speed recovery or prevent subsequent complications, and guidelines now recommend antibiotics for only specific patients. Elective surgical resection is no longer recommended solely based on number of recurrent events or young patient age and might not be necessary for some patients with diverticulitis complicated by abscess. Randomized trials of hemodynamically stable patients who require more emergent surgery for acute, complicated diverticulitis that has not improved with antibiotics provide evidence to support primary anastomosis vs sigmoid colectomy with end colostomy. Despite these advances, more research is needed to increase our understanding of the pathogenesis of diverticulitis and to clarify treatment algorithms. Diverticulitis is a prevalent condition of the colon. New evidence indicates that diet and lifestyle may interact with the gut microbiota to initiate inflammation. Less aggressive treatment paradigms are under active investigation.
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                Author and article information

                Contributors
                roberto.cirocchi@unipg.it
                paolo.sapienza@uniroma1.it
                ang@unife.it
                gianbinda1@gmail.com
                stefano_avenia@libero.it
                salomone.disaverio@gmail.com
                giovanni.tebala@ouh.nhs.uk
                maurozago.md@gmail.com
                annibale.donini@unipg.it
                andrea.mingoli@uniroma1.it
                riccardo.nascimbeni@unibs.it
                Journal
                Langenbecks Arch Surg
                Langenbecks Arch Surg
                Langenbeck's Archives of Surgery
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                1435-2443
                1435-2451
                23 September 2021
                23 September 2021
                2022
                : 407
                : 1
                : 1-14
                Affiliations
                [1 ]GRID grid.9027.c, ISNI 0000 0004 1757 3630, Department of Medicine and Surgery, , University of Perugia, ; 06100 Perugia, Italy
                [2 ]GRID grid.7841.a, Department of Surgery “Pietro Valdoni”, , “Sapienza” University of Rome, ; 00161 Rome, Italy
                [3 ]GRID grid.8484.0, ISNI 0000 0004 1757 2064, Department of Medical Science, , University of Ferrara, ; 4121 Ferrara, Italy
                [4 ]General Surgery, Biomedical Institute, 16157 Genoa, Italy
                [5 ]GRID grid.18147.3b, ISNI 0000000121724807, University of Insubria, ; Varese, Italy
                [6 ]GRID grid.8348.7, ISNI 0000 0001 2306 7492, Surgical Emergency Unit, , John Radcliffe Hospital, Oxford University NHS Foundation Trust, ; Oxford, UK
                [7 ]GRID grid.413175.5, ISNI 0000 0004 0493 6789, Department of Robotic and Emergency Surgery, , Manzoni Hospital, ; 23900 Lecco, Italy
                [8 ]GRID grid.7637.5, ISNI 0000000417571846, Department of Molecular and Translational Medicine, , University of Brescia, ; 25124 Brescia, Italy
                Author information
                http://orcid.org/0000-0002-2457-0636
                Article
                2288
                10.1007/s00423-021-02288-5
                8847191
                34557938
                cba26bce-45f1-49ed-a46c-ca263900e0e7
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 27 June 2021
                : 27 July 2021
                Funding
                Funded by: Università degli Studi di Perugia
                Categories
                State-of-the-Art Clinical Surgery
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2022

                Surgery
                diverticular disease,acute diverticulitis,management,surgical treatment
                Surgery
                diverticular disease, acute diverticulitis, management, surgical treatment

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