For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
13
views
44
references
 Top references
cited by
3
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      376
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Characterizations of alveolar repair after mandibular second molar extraction: an experimental study in rats

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Characterizations of rat mandibular second molar extraction socket with significantly different buccal and lingual alveolar ridge width remain unclear.

          Objective:

          To observe alterations in the alveolar ridge after extraction of mandibular second molars, and to examine processes of alveolar socket healing in an experimental model of alveolar ridge absorption and preservation.

          Methodology:

          Eighteen Wistar rats were included and divided into six groups regarding healing time in the study. Bilateral mandibular second molars were extracted. The rats with tooth extraction sockets took 0, 1.5, 2, 3, 4 and 8 weeks of healing. Histological observation, tartrate-resistant acidic phosphatase (TRAP) staining, Masson’s trichrome staining, immunohistochemical staining and micro-computed tomography (micro-CT) were applied to estimate alterations in the alveolar ridge.

          Results:

          Different buccal and lingual alveolar ridge width led to different height loss. Lingual wall height (LH) decreased significantly two weeks after tooth extraction. Buccal wall height rarely reduced its higher ridge width. From two to eight weeks after extraction, bone volume (BV/TV), density (BMD), and trabecular thickness (Tb.Th) progressively increased in the alveolar socket, which gradually decreased in Tb.Sp and Tb.N. LH showed no significant change during the same period. Osteogenic marker OCN and OPN increased during bone repair from two to eight weeks. The reduced height of the lingual wall of the tooth extraction socket was rarely repaired in the later repair stage. Osteoclast activity led to absorption of the alveolar ridge of the alveolar bone wall within two weeks after operation. We observed positive expression of EMMPRIN and MMP-9 in osteoclasts that participated in the absorption of the spire region.

          Conclusion:

          Extraction of rat mandibular second molars may help the study of alveolar ridge absorption and preservation. The EMMPRIN-MMP-9 pathway may be a candidate for further study on attenuating bone resorption after tooth extraction.

          Related collections

          Most cited references44

          • Record: found
          • Abstract: found
          • Article: not found

          Dimensional ridge alterations following tooth extraction. An experimental study in the dog.

          Mauricio G Araújo, Jan Lindhe (2005)
          To study dimensional alterations of the alveolar ridge that occurred following tooth extraction as well as processes of bone modelling and remodelling associated with such change. Twelve mongrel dogs were included in the study. In both quadrants of the mandible incisions were made in the crevice region of the 3rd and 4th premolars. Minute buccal and lingual full thickness flaps were elevated. The four premolars were hemi-sected. The distal roots were removed. The extraction sites were covered with the mobilized gingival tissue. The extractions of the roots and the sacrifice of the dogs were staggered in such a manner that all dogs contributed with sockets representing 1, 2, 4 and 8 weeks of healing. The animals were sacrificed and tissue blocks containing the extraction socket were dissected, decalcified in EDTA, embedded in paraffin and cut in the buccal-lingual plane. The sections were stained in haematoxyline-eosine and examined in the microscope. It was demonstrated that marked dimensional alterations occurred during the first 8 weeks following the extraction of mandibular premolars. Thus, in this interval there was a marked osteoclastic activity resulting in resorption of the crestal region of both the buccal and the lingual bone wall. The reduction of the height of the walls was more pronounced at the buccal than at the lingual aspect of the extraction socket. The height reduction was accompanied by a "horizontal" bone loss that was caused by osteoclasts present in lacunae on the surface of both the buccal and the lingual bone wall. The resorption of the buccal/lingual walls of the extraction site occurred in two overlapping phases. During phase 1, the bundle bone was resorbed and replaced with woven bone. Since the crest of the buccal bone wall was comprised solely of bundle this modelling resulted in substantial vertical reduction of the buccal crest. Phase 2 included resorption that occurred from the outer surfaces of both bone walls. The reason for this additional bone loss is presently not understood. (c) Blackwell Munksgaard, 2005.
          Article 0 comments Cited 353 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans.

            A Bohra, Connie H Drisko, Margaret Hill … (2003)
            Tooth extraction typically leads to loss of ridge width and height. The primary aim of this 6-month randomized, controlled, blinded, clinical study was to determine whether ridge preservation would prevent post-extraction resorptive changes as assessed by clinical and histologic parameters. Twenty-four patients, 10 males and 14 females, aged 28 to 76 (mean 51.5 +/- 13.6), requiring a non-molar extraction and delayed implant placement were randomly selected to receive either extraction alone (EXT) or ridge preservation (RP) using tetracycline hydrated freeze-dried bone allograft (FDBA) and a collagen membrane. A replaced flap, which did not completely cover the sockets, was used. Following extraction, horizontal and vertical ridge dimensions were determined using a modified digital caliper and an acrylic stent, respectively. Prior to implant placement, a 2.7 x 6.0 mm trephine core was obtained and preserved in formalin for histologic analysis. The width of the RP group decreased from 9.2 +/- 1.2 mm to 8.0 +/- 1.4 mm (P<0.05), while the width of the EXT group decreased from 9.1 +/- 1.0 mm to 6.4 +/- 2.2 mm (P<0.05), a difference of 1.6 mm. Both the EXT and RP groups lost ridge width, although an improved result was obtained in the RP group. Most of the resorption occurred from the buccal; maxillary sites lost more width than mandibular sites. The vertical change for the RP group was a gain of 1.3 +/- 2.0 mm versus a loss of 0.9 +/- 1.6 mm for the EXT group (P<0.05), a height difference of 2.2 mm. Histologic analysis revealed more bone in the RP group: about 65 +/- 10% versus 54 +/- 12% in the EXT group. The RP group included both vital bone (28%) and non-vital (37%) FDBA fragments. Ridge preservation using FDBA and a collagen membrane improved ridge height and width dimensions when compared to extraction alone. These dimensions may be more suitable for implant placement, especially in areas where loss of ridge height would compromise the esthetic result. The quantity of bone observed on histologic analysis was slightly greater in preservation sites, although these sites included both vital and non-vital bone. The most predictable maintenance of ridge width, height, and position was achieved when a ridge preservation procedure was employed.
            Article 0 comments Cited 121 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis.

              Alejandrina G. Ávila-Ortiz, S Elangovan, K Kramer … (2014)
              Alveolar ridge preservation strategies are indicated to minimize the loss of ridge volume that typically follows tooth extraction. The aim of this systematic review was to determine the effect that socket filling with a bone grafting material has on the prevention of postextraction alveolar ridge volume loss as compared with tooth extraction alone in nonmolar teeth. Five electronic databases were searched to identify randomized clinical trials that fulfilled the eligibility criteria. Literature screening and article selection were conducted by 3 independent reviewers, while data extraction was performed by 2 independent reviewers. Outcome measures were mean horizontal ridge changes (buccolingual) and vertical ridge changes (midbuccal, midlingual, mesial, and distal). The influence of several variables of interest (i.e., flap elevation, membrane usage, and type of bone substitute employed) on the outcomes of ridge preservation therapy was explored via subgroup analyses. We found that alveolar ridge preservation is effective in limiting physiologic ridge reduction as compared with tooth extraction alone. The clinical magnitude of the effect was 1.89 mm (95% confidence interval [CI]: 1.41, 2.36; p < .001) in terms of buccolingual width, 2.07 mm (95% CI: 1.03, 3.12; p < .001) for midbuccal height, 1.18 mm (95% CI: 0.17, 2.19; p = .022) for midlingual height, 0.48 mm (95% CI: 0.18, 0.79; p = .002) for mesial height, and 0.24 mm (95% CI: -0.05, 0.53; p = .102) for distal height changes. Subgroup analyses revealed that flap elevation, the usage of a membrane, and the application of a xenograft or an allograft are associated with superior outcomes, particularly on midbuccal and midlingual height preservation.
              Article 0 comments Cited 105 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Appl Oral Sci
                Journal ID (iso-abbrev): J Appl Oral Sci
                Journal ID (publisher-id): jaos
                Title: Journal of Applied Oral Science
                Publisher: Faculdade De Odontologia De Bauru - USP
                ISSN (Print): 1678-7757
                ISSN (Electronic): 1678-7765
                Publication date (Electronic): 08 July 2022
                Publication date Collection: 2022
                Volume: 30
                Electronic Location Identifier: e20220010
                Affiliations
                [1 ] orgnameBinzhou Medical College orgdiv1School of Stomatology Shandong China originalBinzhou Medical College, School of Stomatology, Shandong, China.
                [2 ] orgnameCentral Laboratory of Jinan Stomatological Hospital orgdiv1Jinan Key Laboratory of Oral Tissue Regeneration orgdiv2Department of Endodontics Shandong Province China originalCentral Laboratory of Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Department of Endodontics, Shandong Province, China.
                [3 ] orgnameCentral Laboratory of Jinan Stomatological Hospital orgdiv1Jinan Key Laboratory of Oral Tissue Regeneration orgdiv2Department of Periodontology Shandong Province China originalCentral Laboratory of Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Department of Periodontology, Shandong Province, China.
                [4 ] orgnameCentral Laboratory of Jinan Stomatological Hospital orgdiv1Jinan Key Laboratory of Oral Tissue Regeneration orgdiv2Department of Prosthodontics Shandong Province China originalCentral Laboratory of Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Department of Prosthodontics, Shandong Province, China.
                Author notes
                [*]

                Contributed equally

                Corresponding address: Dr Xijiao Yu and Dr Ronglin Wang, Central Laboratory of Jinan Stomatological Hospital - Jinan Key Laboratory of Oral Tissue Regeneration - Department of Endodontics - Jinan 250001 - Shandong Province - China. e-mail: yayiyu@ 123456163.com/ , Wangronglin212@ 123456sina.com

                Conflict of interest

                The authors declare no conflict of interest.

                Authors’ contributions

                Li, Jianbin : Data curation (Equal); Formal analysis (Equal); Investigation (Equal); Validation (Equal); Writing – original draft (Equal). Sheng, Zhenxian: Data curation (Equal); Formal analysis (Equal); Investigation (Equal); Validation (Equal); Writing – original draft (Equal). Sun, Jing: Data curation (Equal); Investigation (Equal). Wang, Ronglin: Conceptualization (Equal); Methodology (Equal); Project administration (Equal); Resources (Equal); Supervision (Equal); Writing – review and editing (Equal). Yu, Xijiao: Conceptualization (Equal); Funding acquisition (Equal); Methodology (Equal); Project administration (Equal); Resources (Equal); Supervision (Equal); Writing – review and editing (Equal).

                Author information
                https://orcid.org/0000-0001-5047-8342
                https://orcid.org/0000-0001-6837-2378
                https://orcid.org/0000-0003-3534-9205
                https://orcid.org/0000-0002-1269-5618
                https://orcid.org/0000-0002-9289-5520
                Article
                Other ID: 00428
                DOI: 10.1590/1678-7757-2022-0010
                PMC ID: 9275398
                PubMed ID: 35830122
                SO-VID: ca7d508f-deee-4a83-9d7a-ec102cffe00a
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 25 January 2022
                Date revision received : 24 April 2022
                Date accepted : 03 June 2022
                Page count
                Figures: 8, Tables: 0, Equations: 0, References: 38
                Funding
                Funded by: Natural Science Foundation of Shandong Province
                Award ID: ZR2020MH182
                Funded by: Clinical medicine science and technology innovation plan of Jinan
                Award ID: 202019068
                Award ID: 201907099
                Categories
                Subject: Original Article

                Keywords: socket healing,alveolar bone healing,tooth extraction,site preservation
                Data availability:
                Keywords: socket healing, alveolar bone healing, tooth extraction, site preservation

                Comments

                Comment on this article

                scite_

                Similar content376

                See all similar

                Cited by3

                See all cited by

                Most referenced authors451

                See all reference authors