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Abstract
Raised levels of pro-inflammatory, pro-resorptive cytokines during pulmonary infection
may contribute to osteoporosis in cystic fibrosis (CF). We assessed osteoclast number
and activity during infective exacerbations and examined their relationship to serum
inflammatory cytokines and bone turnover markers.
Serum samples from 24 adults with CF were obtained before, during and after treatment
of infection. Osteoclastic cells were generated from peripheral blood mononuclear
cells and their number and activity assessed. Serum osteocalcin, type 1 collagen cross-linked
N-telopeptide (NTx), interleukin-6 (IL-6), tumour necrosis factor alpha (TNFalpha),
receptor activator of NFkB ligand (RANKL) and osteoprotegerin (OPG) were measured.
Osteoclast number and activity were increased at the start of exacerbation and decreased
with antibiotic therapy. Significant correlations were demonstrated between osteoclast
formation and serum TNFalpha, OPG, osteocalcin and NTx and between osteoclast activity
and serum IL-6 and NTx.
The systemic response to infection is associated with increased bone resorptive activity
in patients with CF.
Copyright (c) 2009 European Cystic Fibrosis Society. Published by Elsevier B.V. All
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