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      Cross-National Analysis of the Associations between Traumatic Events and Suicidal Behavior: Findings from the WHO World Mental Health Surveys

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          Abstract

          Background

          Community and clinical data have suggested there is an association between trauma exposure and suicidal behavior (i.e., suicide ideation, plans and attempts). However, few studies have assessed which traumas are uniquely predictive of: the first onset of suicidal behavior, the progression from suicide ideation to plans and attempts, or the persistence of each form of suicidal behavior over time. Moreover, few data are available on such associations in developing countries. The current study addresses each of these issues.

          Methodology/Principal Findings

          Data on trauma exposure and subsequent first onset of suicidal behavior were collected via structured interviews conducted in the households of 102,245 (age 18+) respondents from 21 countries participating in the WHO World Mental Health Surveys. Bivariate and multivariate survival models tested the relationship between the type and number of traumatic events and subsequent suicidal behavior. A range of traumatic events are associated with suicidal behavior, with sexual and interpersonal violence consistently showing the strongest effects. There is a dose-response relationship between the number of traumatic events and suicide ideation/attempt; however, there is decay in the strength of the association with more events. Although a range of traumatic events are associated with the onset of suicide ideation, fewer events predict which people with suicide ideation progress to suicide plan and attempt, or the persistence of suicidal behavior over time. Associations generally are consistent across high-, middle-, and low-income countries.

          Conclusions/Significance

          This study provides more detailed information than previously available on the relationship between traumatic events and suicidal behavior and indicates that this association is fairly consistent across developed and developing countries. These data reinforce the importance of psychological trauma as a major public health problem, and highlight the significance of screening for the presence and accumulation of traumatic exposures as a risk factor for suicide ideation and attempt.

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          Most cited references35

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          Suicide and suicidal behavior.

          Suicidal behavior is a leading cause of injury and death worldwide. Information about the epidemiology of such behavior is important for policy-making and prevention. The authors reviewed government data on suicide and suicidal behavior and conducted a systematic review of studies on the epidemiology of suicide published from 1997 to 2007. The authors' aims were to examine the prevalence of, trends in, and risk and protective factors for suicidal behavior in the United States and cross-nationally. The data revealed significant cross-national variability in the prevalence of suicidal behavior but consistency in age of onset, transition probabilities, and key risk factors. Suicide is more prevalent among men, whereas nonfatal suicidal behaviors are more prevalent among women and persons who are young, are unmarried, or have a psychiatric disorder. Despite an increase in the treatment of suicidal persons over the past decade, incidence rates of suicidal behavior have remained largely unchanged. Most epidemiologic research on suicidal behavior has focused on patterns and correlates of prevalence. The next generation of studies must examine synergistic effects among modifiable risk and protective factors. New studies must incorporate recent advances in survey methods and clinical assessment. Results should be used in ongoing efforts to decrease the significant loss of life caused by suicidal behavior.
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            Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study.

            Suicide is a leading cause of death in the United States, but identifying persons at risk is difficult. Thus, the US surgeon general has made suicide prevention a national priority. An expanding body of research suggests that childhood trauma and adverse experiences can lead to a variety of negative health outcomes, including attempted suicide among adolescents and adults. To examine the relationship between the risk of suicide attempts and adverse childhood experiences and the number of such experiences (adverse childhood experiences [ACE] score). A retrospective cohort study of 17 337 adult health maintenance organization members (54% female; mean [SD] age, 57 [15.3] years) who attended a primary care clinic in San Diego, Calif, within a 3-year period (1995-1997) and completed a survey about childhood abuse and household dysfunction, suicide attempts (including age at first attempt), and multiple other health-related issues. Self-reported suicide attempts, compared by number of adverse childhood experiences, including emotional, physical, and sexual abuse; household substance abuse, mental illness, and incarceration; and parental domestic violence, separation, or divorce. The lifetime prevalence of having at least 1 suicide attempt was 3.8%. Adverse childhood experiences in any category increased the risk of attempted suicide 2- to 5-fold. The ACE score had a strong, graded relationship to attempted suicide during childhood/adolescence and adulthood (P<.001). Compared with persons with no such experiences (prevalence of attempted suicide, 1.1%), the adjusted odds ratio of ever attempting suicide among persons with 7 or more experiences (35.2%) was 31.1 (95% confidence interval, 20.6-47.1). Adjustment for illicit drug use, depressed affect, and self-reported alcoholism reduced the strength of the relationship between the ACE score and suicide attempts, suggesting partial mediation of the adverse childhood experience-suicide attempt relationship by these factors. The population-attributable risk fractions for 1 or more experiences were 67%, 64%, and 80% for lifetime, adult, and childhood/adolescent suicide attempts, respectively. A powerful graded relationship exists between adverse childhood experiences and risk of attempted suicide throughout the life span. Alcoholism, depressed affect, and illicit drug use, which are strongly associated with such experiences, appear to partially mediate this relationship. Because estimates of the attributable risk fraction caused by these experiences were large, prevention of these experiences and the treatment of persons affected by them may lead to progress in suicide prevention.
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              The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI).

              This paper presents an overview of the World Mental Health (WMH) Survey Initiative version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) and a discussion of the methodological research on which the development of the instrument was based. The WMH-CIDI includes a screening module and 40 sections that focus on diagnoses (22 sections), functioning (four sections), treatment (two sections), risk factors (four sections), socio-demographic correlates (seven sections), and methodological factors (two sections). Innovations compared to earlier versions of the CIDI include expansion of the diagnostic sections, a focus on 12-month as well as lifetime disorders in the same interview, detailed assessment of clinical severity, and inclusion of information on treatment, risk factors, and consequences. A computer-assisted version of the interview is available along with a direct data entry software system that can be used to keypunch responses to the paper-and-pencil version of the interview. Computer programs that generate diagnoses are also available based on both ICD-10 and DSM-IV criteria. Elaborate CD-ROM-based training materials are available to teach interviewers how to administer the interview as well as to teach supervisors how to monitor the quality of data collection.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2010
                13 May 2010
                : 5
                : 5
                : e10574
                Affiliations
                [1 ]Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa
                [2 ]Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, United States of America
                [3 ]Health Services Research Unit, Institut Municipal d'Investigació Mèdica (IMIM-Hospital del Mar), CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
                [4 ]Department of Epidemiological Research, Division of Epidemiological and Psychosocial Research, National Institute of Psychiatry (Mexico) and Metropolitan Autonomous University, Mexico City, Mexico
                [5 ]Department of Psychiatry, State University of New York at Stony Brook, New York, United States of America
                [6 ]University Hospital Gasthuisberg, Leuven, Belgium
                [7 ]Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
                [8 ]National School of Public Health and Health Services Management, Bucharest, Romania
                [9 ]University College Hospital, Ibadan, Nigeria
                [10 ]Shanghai Mental Health Center, Shanghai, China
                [11 ]EA 4069 Université Paris Descartes, Paris, France
                [12 ]Research and Planning, Mental Health Services, Ministry of Health, Jerusalem, Israel
                [13 ]Clinic of Psychiatry, University of Leipzig, Leipzig, Germany
                [14 ]Institute for Development, Research, Advocacy and Applied Care (IDRAAC), Beirut, Lebanon
                [15 ]Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America
                [16 ]School of Public Health, Jichi Medical University, Tochigi-ken, Japan
                [17 ]Department of Psychiatry and Psychiatric Epidemiology, University Medical Center Groningen, University Center for Psychiatry, Groningen, Netherlands
                [18 ]Centro Medico de la Sabana, Universidad Javerina, Bogota, Colombia
                [19 ]Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India
                [20 ]Department of Psychological Medicine, Wellington School of Medicine and Health Sciences, Otago, New Zealand
                [21 ]Institute for Human Relations, New Bulgarian University, Sofia, Bulgaria
                [22 ]Department of Psychiatric Epidemiology, Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil
                [23 ]Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
                [24 ]Department of Psychology, Harvard University, Cambridge, Massachusetts, United States of America
                CIET, Canada
                Author notes

                Conceived and designed the experiments: DJS RCK JA GB EB RB GdG SF OG YH VKM DL HM JO JPV RS KMS TT MCV DRW. Performed the experiments: JA GB RB GdG SF OG YH VKM DL HM ZM YN JO JPV RS KMS TT MCV DRW. Analyzed the data: DJS WTC IH RCK NS MKN. Contributed reagents/materials/analysis tools: DJS RCK MKN. Wrote the paper: DJS RCK MKN. Critical revision of the manuscript: WTC IH NS JA GB EB RB GdG SF OG YH V-KM DL HM ZM YN JO JP-V RS KMS TT MCV DRW MKN. Experiments referring to the survey fieldwork done in each country: JA GB EB RB GdG SF OG YH V-KM DL HM ZM YN JO JP-V RS KMS TT MCV DRW.

                Article
                09-PONE-RA-15100R1
                10.1371/journal.pone.0010574
                2869349
                20485530
                c9f42c03-0b03-47c8-92dd-60b8cb1bfd54
                Stein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                : 22 December 2009
                : 16 April 2010
                Page count
                Pages: 13
                Categories
                Research Article
                Mental Health/Psychology
                Public Health and Epidemiology/Global Health
                Public Health and Epidemiology/Social and Behavioral Determinants of Health

                Uncategorized
                Uncategorized

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