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      Post-traumatic Stress Disorder Symptoms in COVID-19 Survivors 6 Months After Hospital Discharge: An Application of the Conservation of Resource Theory

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          Abstract

          COVID-19 survivors who had acute respiratory symptoms might experience prolonged post-traumatic stress disorder (PTSD) due to further rehabilitation, somatic symptoms and related distress. The conservation of resource (COR) theory is a well-developed theory to understand how people develop PTSD symptoms in traumatic events. The current study aimed to examine the potential factors of PTSD symptoms and interrelationships among this factors among COVID-19 survivors based on the COR theory. This cross-sectional telephone survey enrolled 199 COVID-19 patients (Mean age = 42.7; 53.3% females) 6 months after their hospital discharge in five Chinese cities (i.e., Wuhan, Shenzhen, Zhuhai, Dongguan, and Nanning). The results showed that 7% of participants were classified as having probable PTSD. The significant potential factors relating to PTSD symptoms included socio-demographic status, hospitalization experiences, post-hospitalization experiences, and psychological status. Besides, the proposed statistical mediation model based on the COR framework showed good model fit, χ 2(df) = 17.286 (5), p = 0.004, CFI = 0.962, NNFI = 0.951, RMSEA = 0.077. Perceived resource loss/gain fully mediated the association between exposure to other patients' suffering during hospitalization and PTSD symptoms, and partially mediated the relationships from somatic symptoms/perceived impact of being infected with COVID-19 after discharge to PTSD symptoms. On the other hand, resilience was a full mediator in the relationship from ICU experience to PTSD symptoms and a partial mediator in the relationship from perceived impact to PTSD symptoms. The results provide preliminary support on applying the COR theory to understand the factors of PTSD symptoms among COVID-19 survivors. Interventions to reduce PTSD symptoms in this population can be developed based on the modifiable psychosocial mediators.

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          Conservation of resources: A new attempt at conceptualizing stress.

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            Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors

            Highlights • COVID-19, such as other coronaviruses, is associated with psychiatric implication. • 55% of the sample presented a clinical score for at least one mental disorder. • Psychiatric history, setting, and length of hospitalization influenced psychopathology. • Females suffered more than males, scoring higher in all the measures. • There is the need to diagnose and treat psychiatric sequelae in COVID-19 survivors.
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              Posttraumatic stress symptoms and attitude toward crisis mental health services among clinically stable patients with COVID-19 in China

              The novel coronavirus disease (COVID-19) has been rapidly transmitted globally. With the increasing number of infected cases and deaths, many patients experienced both physical suffering and great psychological distress. In China, a range of guidelines and expert consensus have been developed by health authorities and academic associations. Crisis mental health interventions, such as online education and counseling services, have been widely adopted nationwide (Liu et al., 2020). According to the treatment guidelines in China, COVID-19 patients need to be treated in isolated hospitals. Due to social isolation, perceived danger, uncertainty, physical discomfort, medication side effects, fear of virus transmission to others, and negative news on social media, patients with COVID-19 may experience loneliness, anger, anxiety, depression, insomnia, and posttraumatic stress symptoms (Wu, Chan, & Ma, 2005; Xiang et al., 2020), which could negatively affect individuals' social and occupational functioning, and quality of life (Monson, Caron, McCloskey, & Brunet, 2017; North et al., 2002). To date, no studies on the pattern of posttraumatic stress symptoms among COVID-19 patients have been reported. Therefore, we examined the pattern of posttraumatic stress symptoms in clinically stable COVID-19 patients. We also explored patients' attitude toward crisis mental health services during the COVID-19 outbreak. Online assessment was incorporated as part of the crisis psychological interventions. Patients were invited to participate in this online assessment prior to their discharge from five quarantine facilities (‘Fang Cang’ hospitals) in Wuhan, Hubei province in March 2020. ‘Fang Cang’ hospitals refer to temporary quarantine hospital facilities converted from gymnasiums, exhibition centers and sports centers for clinically stable patients with COVID-19 in Wuhan, China. To be eligible, participants should be adult patients diagnosed with COVID-19 verified by patients' medical records, and clinically stable, as screened by patients' case medical officers. Participants were asked about their attitudes toward COVID-19-related online crisis mental health services, such as psycho-educational resources, and mental health counseling, using a standardized question: ‘Do you think online psycho-educational resources and mental health counseling provision during the COVID-19 outbreak are helpful?’ (yes/no). The amended self-reported Posttraumatic Stress Disorder (PTSD) Checklist– Civilian Version (PCL-C) (Weathers, Litz, Herman, Huska, & Keane, 1993) was used to assess the severity of the posttraumatic stress symptoms associated with the COVID-19. A total PCL-C score of ⩾50 was considered ‘having significant posttraumatic stress symptoms’ (Yang, Yang, Liu, & Yang, 2007). A total of 730 COVID-19 patients were recruited in this study, of whom, 714 met the inclusion criteria. The mean age of the participants was 50.2 ± 12.9 years, men accounted for 49.1% of the sample, and 25.8% lived alone prior to admission. The prevalence of significant posttraumatic stress symptoms associated with the COVID-19 was 96.2% (95% CI 94.8–97.6%). Half of the participants (49.8%) considered psycho-educational services helpful. To the best of our knowledge, this was the first study examining the prevalence of posttraumatic stress symptoms in COVID-19 patients. It is noteworthy that most COVID-19 patients suffered from significant posttraumatic stress symptoms associated with the disease prior to discharge, and these symptoms may lead to negative outcomes, such as lower quality of life and impaired working performance. Following the outbreak of severe acute respiratory syndrome (SARS) in 2003, the prevalence of PTSD in SARS survivors was 9.79% in their early recovery phase (Fang, Zhe, & Shuran, 2004) and 25.6% at 30-month post-SARS assessment (Mak, Chu, Pan, Yiu, & Chan, 2009). Our findings were significantly higher than that of Fang's and Mak's. The remarkable differences between these studies could be attributed to different clinical diagnosis and illness phrases (e.g., clinically stable COVID-19 inpatients vs. SARS survivors) and different measurements (e.g., self-reported instrument on posttraumatic stress symptoms associated with the COVID-19 vs. clinical diagnosis of PTSD established by professionals). The rapid transmission of COVID-19 alongside with demeaning news coverage in widely used communication programs (e.g. WeChat and Weibo), and social discrimination toward COVID-19 patients may result in higher prevalence of self-perceived posttraumatic stress symptoms associated with the COVID-19 in this study. Of particular note was that only half of the patients hold positive attitudes toward online crisis mental health services. During the COVID-19 outbreak, most crisis mental health services for infected patients are delivered online. Many COVID-19 patients were older adults with limited time, and restricted access to internet and smartphones due to poor health status during hospitalization (Yang et al., 2020). Compared with on-site psychological interventions, online self-guided psycho-educational resources could be less effective, especially for those with reading difficulties and physical discomfort brought by COVID-19 and treatment side effects. In conclusion, this study found that most clinically stable COVID-19 patients suffered from significant posttraumatic stress symptoms associated with the COVID-19 prior to discharge. Considering the negative detrimental impact of significant posttraumatic stress symptoms, appropriate crisis psychological interventions and long-term follow-up assessments should be urgently initiated for COVID-19 survivors.
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                Author and article information

                Contributors
                Journal
                Front Psychiatry
                Front Psychiatry
                Front. Psychiatry
                Frontiers in Psychiatry
                Frontiers Media S.A.
                1664-0640
                04 January 2022
                2021
                04 January 2022
                : 12
                : 773106
                Affiliations
                [1] 1School of Public Health (Shenzhen), Sun Yat-sen University , Shenzhen, China
                [2] 2The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong , Hong Kong SAR, China
                [3] 3Center for Optometry and Visual Science, The People's Hospital of Guangxi Zhuang Autonomous Region , Nanning, China
                [4] 4Department of Early Childhood Education, The Education University of Hong Kong, Hong Kong , Hong Kong SAR, China
                [5] 5The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai, China
                [6] 6Guangdong Provincial People's Hospital , Guangzhou, China
                [7] 7Department of Scientific Research, The People's Hospital of Guangxi Zhuang Autonomous Region , Nanning, China
                [8] 8Department of Education, The People's Hospital of Guangxi Zhuang Autonomous Region , Nanning, China
                [9] 9Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region , Nanning, China
                [10] 10Department of Emergency, SSL Central Hospital of Dongguan City , Dongguan, China
                [11] 11Shenzhen Nanshan District Center for Disease Control and Prevention , Shenzhen, China
                [12] 12School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai, China
                [13] 13Shenzhen Center for Disease Control and Prevention , Shenzhen, China
                [14] 14Kirby Institute, University of New South Wales , Sydney, NSW, Australia
                Author notes

                Edited by: Tingzhong Yang, Zhejiang University, China

                Reviewed by: Mark C. M. Tsang, Tung Wah College, Hong Kong SAR, China; Julian Ford, UCONN Health, United States

                *Correspondence: Fei Xiao xiaof35@ 123456mail.sysu.edu.cn

                This article was submitted to Public Mental Health, a section of the journal Frontiers in Psychiatry

                †These authors have contributed equally to this work and share first authorship

                ‡These authors have contributed equally to this work and share corresponding authorship

                Article
                10.3389/fpsyt.2021.773106
                8764385
                35058820
                c977ffd8-f4d1-44a3-8ebc-c15d3a6b61fa
                Copyright © 2022 Wang, Yang, Fu, Hu, Luo, Xiao, Ju, Zheng, Xu, Fang, Chan, Xu, Chen, He, Zhu, Tang, Huang, Hong, Ma, Hao, Cai, Yang, Ye, Yuan, Chen, Xiao, Wang and Zou.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 09 September 2021
                : 02 December 2021
                Page count
                Figures: 1, Tables: 2, Equations: 0, References: 47, Pages: 11, Words: 7826
                Categories
                Psychiatry
                Original Research

                Clinical Psychology & Psychiatry
                post-traumatic stress disorder (ptsd),hospitalization-related factors,resource loss and gain,resilience,conservation of resource theory (cor)

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