Valganciclovir for symptomatic congenital cytomegalovirus disease.

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Abstract

The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time.

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Congenital cytomegalovirus (CMV) infection and hearing deficit.

S Boppana, K. Fowler (2006)

The association between congenital cytomegalovirus (CMV) infection and sensorineural hearing loss (SNHL) was first described in 1964. Studies over the past four decades have further described the relationship between congenital CMV infection and SNHL in children. This manuscript will review the current knowledge of CMV-related SNHL and summarize the studies completed at the University of Alabama at Birmingham (UAB). A review of the series of studies at UAB that has led to a more detailed characterization of hearing loss due to congenital CMV infection. Approximately, 22%-65% of symptomatic and 6%-23% of asymptomatic children will have hearing loss following congenital CMV infection. CMV-related SNHL may be present at birth or occur later in childhood. Variability in the severity of CMV-related hearing loss ranges from unilateral high frequency losses to profound bilateral losses. Congenital CMV infection significantly contributes to SNHL in many infant populations. Although, most children with congenital CMV infection do not develop hearing loss, it is difficult to predict which children with congenital CMV infection will develop hearing loss and, among those who do develop loss, whether or not the loss will continue to deteriorate.

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Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection.

Karen Fowler, Faye P. McCollister, Arthur Dahle … (1997)

To determine the prevalence and temporal changes of sensorineural hearing loss (SNHL) among children with clinically inapparent (asymptomatic) congenital cytomegalovirus (CMV) infection identified from a cohort of newborn infants screened for congenital CMV infection. The study population consisted of 307 children with documented asymptomatic congenital CMV infection, 76 uninfected siblings of children with asymptomatic congenital CMV infection, and 201 children whose neonatal screen for congenital CMV infection showed negative results. Audiologic evaluations were completed for all children to determine their hearing status. SNHL occurred only in children with congenital CMV infection. Of the children with asymptomatic congenital CMV infection, 22 (7.2%; 95% confidence interval, 4.5% to 10.6%) had SNHL. Among the children with hearing loss, further deterioration of hearing occurred in 50.0%, with the median age at first progression at 18 months (range, 2 to 70 months). Delayed-onset SNHL was observed in 18.2% of the children, with the median age of detection at 27 months (range, 25 to 62 months). Fluctuating SNHL was documented in 22.7% of the children with hearing loss. Asymptomatic congenital CMV infection is likely a leading cause of SNHL in young children. The continued deterioration of hearing and delayed onset of SNHL in these children emphasizes the need for continued monitoring of their hearing status.

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Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero.

S Elek-Vlajic, Alan Stern (1974)

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Journal

Journal ID (iso-abbrev): N. Engl. J. Med.

Title: The New England journal of medicine

ISSN (Electronic): 1533-4406

ISSN (Print): 0028-4793

Publication date (Electronic): Mar 5 2015

Volume: 372

Issue: 10

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[1 ] The authors' affiliations are listed in the Appendix.

Article

Mid ID: NIHMS677073

DOI: 10.1056/NEJMoa1404599

PubMed ID: 25738669

SO-VID: c8ebca63-0c58-40b6-bb9e-38c89615fb47

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Valganciclovir for symptomatic congenital cytomegalovirus disease.

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Abstract

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Most cited references 8

Congenital cytomegalovirus (CMV) infection and hearing deficit.

Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection.

Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero.

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