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      Why Is Long-Term Therapy Required to Cure Tuberculosis?

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      Author(s): , , *
      Publication date (Electronic):
      Journal: PLoS Medicine
      Publisher: Public Library of Science

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          Abstract

          The authors argue that understanding and countering general bacterial mechanisms of phenotypic antibiotic resistance may hold the key to reducing the duration of treatment of all recalcitrant bacterial infections, including tuberculosis.

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          Bacterial persistence as a phenotypic switch.

          Nathalie Q Balaban, Jack Merrin, Remy Chait … (2004)
          A fraction of a genetically homogeneous microbial population may survive exposure to stress such as antibiotic treatment. Unlike resistant mutants, cells regrown from such persistent bacteria remain sensitive to the antibiotic. We investigated the persistence of single cells of Escherichia coli with the use of microfluidic devices. Persistence was linked to preexisting heterogeneity in bacterial populations because phenotypic switching occurred between normally growing cells and persister cells having reduced growth rates. Quantitative measurements led to a simple mathematical description of the persistence switch. Inherent heterogeneity of bacterial populations may be important in adaptation to fluctuating environments and in the persistence of bacterial infections.
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            Persister cells, dormancy and infectious disease.

            Kim Lewis (2007)
            Several well-recognized puzzles in microbiology have remained unsolved for decades. These include latent bacterial infections, unculturable microorganisms, persister cells and biofilm multidrug tolerance. Accumulating evidence suggests that these seemingly disparate phenomena result from the ability of bacteria to enter into a dormant (non-dividing) state. The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review.
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              TREATMENT OF STAPHYLOCOCCAL INFECTIONS WITH PENICILLIN BY INTERMITTENT STERILISATION

              JosephW. Bigger (1944)
              Article 0 comments Cited 293 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): PLoS Med
                Journal ID (publisher-id): pmed
                Title: PLoS Medicine
                Publisher: Public Library of Science (San Francisco, USA )
                ISSN (Print): 1549-1277
                ISSN (Electronic): 1549-1676
                Publication date (Print): March 2007
                Publication date (Electronic): 20 March 2007
                Volume: 4
                Issue: 3
                Electronic Location Identifier: e120
                Author notes
                * To whom correspondence should be addressed. E-mail: lalitar@ 123456u.washington.edu
                Article
                Publisher ID: 06-PLME-RIT-0481R2
                DOI: 10.1371/journal.pmed.0040120
                PMC ID: 1831743
                PubMed ID: 17388672
                SO-VID: c8e90630-b1de-4c42-b7ca-6c27ff75db8b
                Copyright © © 2007 Connolly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                Page count
                Pages: 8
                Categories
                Subject: Research in Translation
                Subject: Infectious Diseases
                Subject: Infectious Diseases
                Subject: Infectious Diseases
                Subject: Infectious Diseases
                Subject: Microbiology
                Subject: Microbiology
                Subject: Microbiology
                Subject: Microbiology
                Subject: Pharmacology
                Subject: Pharmacology
                Subject: Pharmacology
                Subject: Public Health and Epidemiology
                Subject: Tuberculosis
                Subject: Infectious Diseases
                Subject: Microbiology
                Subject: Pharmacology and Toxicology
                Subject: Drugs and Adverse Drug Reactions
                Custom metadata
                citation Connolly LE, Edelstein PH, Ramakrishnan L (2007) Why is long-term therapy required to cure tuberculosis? PLoS Med 4(3): e120. doi: 10.1371/journal.pmed.0040120

                ScienceOpen disciplines: Medicine
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                ScienceOpen disciplines: Medicine

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