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      MRI-Based Brain Tumor Classification Using Ensemble of Deep Features and Machine Learning Classifiers

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          Abstract

          Brain tumor classification plays an important role in clinical diagnosis and effective treatment. In this work, we propose a method for brain tumor classification using an ensemble of deep features and machine learning classifiers. In our proposed framework, we adopt the concept of transfer learning and uses several pre-trained deep convolutional neural networks to extract deep features from brain magnetic resonance (MR) images. The extracted deep features are then evaluated by several machine learning classifiers. The top three deep features which perform well on several machine learning classifiers are selected and concatenated as an ensemble of deep features which is then fed into several machine learning classifiers to predict the final output. To evaluate the different kinds of pre-trained models as a deep feature extractor, machine learning classifiers, and the effectiveness of an ensemble of deep feature for brain tumor classification, we use three different brain magnetic resonance imaging (MRI) datasets that are openly accessible from the web. Experimental results demonstrate that an ensemble of deep features can help improving performance significantly, and in most cases, support vector machine (SVM) with radial basis function (RBF) kernel outperforms other machine learning classifiers, especially for large datasets.

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          The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

          The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M-mutant; RELA fusion-positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumour with multilayered rosettes, C19MC-altered. The 2016 edition has added newly recognized neoplasms, and has deleted some entities, variants and patterns that no longer have diagnostic and/or biological relevance. Other notable changes include the addition of brain invasion as a criterion for atypical meningioma and the introduction of a soft tissue-type grading system for the now combined entity of solitary fibrous tumor / hemangiopericytoma-a departure from the manner by which other CNS tumors are graded. Overall, it is hoped that the 2016 CNS WHO will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors.
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            ImageNet classification with deep convolutional neural networks

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              A Decision-Theoretic Generalization of On-Line Learning and an Application to Boosting

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                Author and article information

                Contributors
                Role: Academic Editor
                Role: Academic Editor
                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                22 March 2021
                March 2021
                : 21
                : 6
                : 2222
                Affiliations
                [1 ]Department of Software, Korea National University of Transportation, Chungju 27469, Korea; kjysmu@ 123456ut.ac.kr (J.K.); zahid@ 123456ut.ac.kr (Z.U.)
                [2 ]Department of Biomedical Engineering, Korea National University of Transportation, Chungju 27469, Korea
                [3 ]Department of AI Robotics Engineering, Korea National University of Transportation, Chungju 27469, Korea
                [4 ]Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation, Chungju 27469, Korea
                Author notes
                [* ]Correspondence: jgwak@ 123456ut.ac.kr ; Tel.: +82-43-841-5852
                Author information
                https://orcid.org/0000-0003-1211-2678
                Article
                sensors-21-02222
                10.3390/s21062222
                8004778
                33810176
                c880ad36-9bc3-4d41-a830-7c326b841979
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 10 February 2021
                : 17 March 2021
                Categories
                Article

                Biomedical engineering
                deep learning,ensemble learning,brain tumor classification,machine learning,transfer learning

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