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      The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers

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          Abstract

          Introduction

          Europe is an important focus for compiling accurate and up-to-date world cancer statistics owing to its large share of the world's total cancer burden. This article presents incidence and mortality estimates for 25 major cancers across 40 individual countries within European areas and the European Union (EU-27) for the year 2020.

          Methods

          The estimated national incidence and mortality rates are based on statistical methodology previously applied and verified using the most recently collected incidence data from 151 population-based cancer registries, mortality data and 2020 population estimates.

          Results

          Estimates reveal 4 million new cases of cancer (excluding non-melanoma skin cancer) and 1.9 million cancer-related deaths. The most common cancers are: breast in women (530,000 cases), colorectum (520,000), lung (480,000) and prostate (470,000). These four cancers account for half the overall cancer burden in Europe. The most common causes of cancer deaths are: lung (380,000), colorectal (250,000), breast (140,000) and pancreatic (130,000) cancers. In EU-27, the estimated new cancer cases are approximately 1.4 million in males and 1.2 million in females, with over 710,000 estimated cancer deaths in males and 560,000 in females.

          Conclusion

          The 2020 estimates provide a basis for establishing priorities in cancer-control measures across Europe. The long-established role of cancer registries in cancer surveillance and the evaluation of cancer control measures remain fundamental in formulating and adapting national cancer plans and pan-European health policies. Given the estimates are built on recorded data prior to the onset of coronavirus disease 2019 (COVID-19), they do not take into account the impact of the pandemic.

          Highlights

          • The 2020 incidence estimates derived from 151 population-based cancer registries' data.

          • Over 4 million new cancer cases and 1.9 million cancer-related deaths are estimated in Europe for 2020.

          • Half the overall cancer diagnoses are from breast , colorectal , lung and prostate cancers.

          • The most common cancer-related deaths are from lung , colorectal , breast and pancreatic cancers.

          • The 2020 estimates are key to assess and monitor cancer-control measures across Europe.

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          Most cited references42

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          Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

          Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer statistics in 185 countries. The validity of the national estimates depends upon the representativeness of the source information, and to take into account possible sources of bias, uncertainty intervals are now provided for the estimated sex- and site-specific all-ages number of new cancer cases and cancer deaths. We briefly describe the key results globally and by world region. There were an estimated 18.1 million (95% UI: 17.5-18.7 million) new cases of cancer (17 million excluding non-melanoma skin cancer) and 9.6 million (95% UI: 9.3-9.8 million) deaths from cancer (9.5 million excluding non-melanoma skin cancer) worldwide in 2018.
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            Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

            Europe contains 9% of the world population but has a 25% share of the global cancer burden. Up-to-date cancer statistics in Europe are key to cancer planning. Cancer incidence and mortality estimates for 25 major cancers are presented for the 40 countries in the four United Nations-defined areas of Europe and for Europe and the European Union (EU-28) for 2018.
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              Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012.

              Cancer incidence and mortality estimates for 25 cancers are presented for the 40 countries in the four United Nations-defined areas of Europe and for the European Union (EU-27) for 2012. We used statistical models to estimate national incidence and mortality rates in 2012 from recently-published data, predicting incidence and mortality rates for the year 2012 from recent trends, wherever possible. The estimated rates in 2012 were applied to the corresponding population estimates to obtain the estimated numbers of new cancer cases and deaths in Europe in 2012. There were an estimated 3.45 million new cases of cancer (excluding non-melanoma skin cancer) and 1.75 million deaths from cancer in Europe in 2012. The most common cancer sites were cancers of the female breast (464,000 cases), followed by colorectal (447,000), prostate (417,000) and lung (410,000). These four cancers represent half of the overall burden of cancer in Europe. The most common causes of death from cancer were cancers of the lung (353,000 deaths), colorectal (215,000), breast (131,000) and stomach (107,000). In the European Union, the estimated numbers of new cases of cancer were approximately 1.4 million in males and 1.2 million in females, and around 707,000 men and 555,000 women died from cancer in the same year. These up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe. The important role of cancer registries in disease surveillance and in planning and evaluating national cancer plans is becoming increasingly recognised, but needs to be further advocated. The estimates and software tools for further analysis (EUCAN 2012) are available online as part of the European Cancer Observatory (ECO) (http://eco.iarc.fr). Copyright © 2013 Elsevier Ltd. All rights reserved.
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                Author and article information

                Contributors
                Journal
                Eur J Cancer
                Eur J Cancer
                European Journal of Cancer
                Elsevier Science Ltd
                0959-8049
                1879-0852
                1 November 2021
                November 2021
                : 157
                : 308-347
                Affiliations
                [a ]European Commission, Joint Research Centre (JRC), Ispra, Italy
                [b ]Cancer Surveillance Branch, International Agency for Research on Cancer (IARC), Lyon, France
                [c ]Northern Ireland Cancer Registry, Belfast, United Kingdom
                Author notes
                [1]

                These authors contributed equally to the work.

                Article
                S0959-8049(21)00497-4
                10.1016/j.ejca.2021.07.039
                8568058
                34560371
                c70c9471-786e-4734-91a0-5fd93e6bf3f9
                © 2021 The Authors

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

                History
                : 16 July 2021
                : 28 July 2021
                Categories
                Original Research

                Oncology & Radiotherapy
                cancer registries,cancer,europe,incidence,mortality,estimation
                Oncology & Radiotherapy
                cancer registries, cancer, europe, incidence, mortality, estimation

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