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      Health‐related quality of life in patients with esophageal cancer or precancerous lesions assessed by EQ‐5D: A multicenter cross‐sectional study

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          Abstract

          Background

          We aimed to obtain a set of health state utility scores of patients with esophageal cancer (EC) and precancerous lesions in China, and to explore the influencing factors of health‐related quality of life (HRQoL).

          Methods

          A hospital‐based multicenter cross‐sectional study was conducted. From 2013 to 2014, patients with EC or precancerous lesions were enrolled. HRQoL was assessed using a European quality of life‐5 dimension (EQ‐5D‐3L) instrument. Multivariable linear regression analysis was performed to explore the influencing factors of the EQ‐5D utility scores.

          Results

          A total of 2090 EC patients and 156 precancer patients were included in the study. The dimension of pain/discomfort had the highest rate of self‐reported problems, 60.5% in EC and 51.3% in precancer patients. The mean visual analog scale (VAS) score for EC and precancer patients were 68.4 ± 0.7 and 64.5 ± 3.1, respectively. The EQ‐5D utility scores for EC and precancer patients were estimated as 0.748 ± 0.009 and 0.852 ± 0.022, and the scores of EC at stage I, stage II, stage III, and stage IV were 0.693 ± 0.031, 0.747 ± 0.014, 0.762 ± 0.015, and 0.750 ± 0.023, respectively. According to the multivariable analyses, the factors of region, occupation, household income in 2012, health care insurance type, pathological type, type of therapy, and time points of the survey were statistically associated with the EQ‐5D utility scores of EC patients.

          Conclusions

          There were remarkable decrements of utility scores among esophageal cancer patients, compared with precancer patients. The specific utility scores of EC would support further cost‐utility analysis in populations in China.

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          Most cited references55

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          Estimating an EQ-5D-5L Value Set for China.

          To estimate a five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) value set for China using the health preferences of residents living in the urban areas of the country.
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            A program of methodological research to arrive at the new international EQ-5D-5L valuation protocol.

            To describe the research that has been undertaken by the EuroQol Group to improve current methods for health state valuation, to summarize the results of an extensive international pilot program, and to outline the key elements of the five-level EuroQol five-dimensional (EQ-5D-5L) questionnaire valuation protocol, which is the culmination of that work.
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              Chinese time trade-off values for EQ-5D health states.

              To generate a Chinese general population-based three-level EuroQol five-dimensios (EQ-5D-3L) social value set using the time trade-off method.
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                Author and article information

                Contributors
                shijf@cicams.ac.cn
                dulb@zjcc.org.cn
                Journal
                Thorac Cancer
                Thorac Cancer
                10.1111/(ISSN)1759-7714
                TCA
                Thoracic Cancer
                John Wiley & Sons Australia, Ltd (Melbourne )
                1759-7706
                1759-7714
                04 March 2020
                April 2020
                : 11
                : 4 ( doiID: 10.1111/tca.v11.4 )
                : 1076-1089
                Affiliations
                [ 1 ] Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences/Department of Cancer Prevention, Cancer Hospital of the University of Chinese Academy of Sciences/Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou China
                [ 2 ] Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
                [ 3 ] Institute of Epidemiology and Health Statistics Lanzhou University Lanzhou China
                [ 4 ] Hunan Office for Cancer Control and Research Hunan Provincial Cancer Hospital Changsha China
                [ 5 ] Public Health Information Research Office, Institute of Medical Information Chinese Academy of Medical Sciences Beijing China
                [ 6 ] Department of Health Economics, School of Health Management Harbin Medical University Harbin China
                [ 7 ] Center for Health Management and Policy, Key Lab of Health Economics and Policy Shandong University Jinan China
                [ 8 ] Science and Education Department of Public Health Division Shandong Tumor Hospital Jinan China
                [ 9 ] Chongqing Office for Cancer Control and Research Chongqing Cancer Hospital Chongqing China
                [ 10 ] Department of Institute of Tumor Research Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Zhengzhou China
                [ 11 ] Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical University Urumqi China
                [ 12 ] Liaoning Office for Cancer Control and Research Liaoning Cancer Hospital & Institute Shenyang China
                [ 13 ] Cancer Epidemiology Research Center Gansu Provincial Cancer Hospital Lanzhou China
                [ 14 ] Urban Office of Cancer Early Detection and Treatment Tieling Central Hospital Tieling China
                [ 15 ] Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University Harbin China
                [ 16 ] Institute of Chronic Disease Prevention and Control Harbin Center for Disease Control and Prevention Harbin China
                [ 17 ] Institute of Chronic Non‐communicable Diseases Prevention and Control Jiangsu Provincial Center for Disease Control and Prevention Nanjing China
                [ 18 ] Department of Control and Prevention of Chronic Non‐Communicable Diseases Xuzhou Center for Disease Control and Prevention Xuzhou China
                [ 19 ] Ningbo Clinical Cancer Prevention Guidance Center Ningbo No.2 Hospital Ningbo China
                [ 20 ] Department of Occupational Medicine Tangshan People's Hospital Tangshan China
                [ 21 ] Health Department of Kailuan Group Kailuan General Hospital Tangshan China
                Author notes
                [*] [* ] Correspondence

                Jufang Shi, Office for Cancer Screening, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan Lane, Chaoyang District, Beijing 100021, China.

                Tel: +86 10 8778 7396

                Email: shijf@ 123456cicams.ac.cn

                Lingbin Du, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences/Department of Cancer Prevention, Cancer Hospital of the University of Chinese Academy of Sciences/Department of Cancer Prevention, Zhejiang Cancer Hospital, 1 East Banshan Road, Gongshu District, Hangzhou 310022, China.

                Tel: +86 571 8812 2219

                Email: dulb@ 123456zjcc.org.cn

                Author information
                https://orcid.org/0000-0002-1992-7784
                Article
                TCA13368
                10.1111/1759-7714.13368
                7113059
                32130756
                c6ff62fa-ad2c-4580-910b-6443fd9b6155
                © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 22 November 2019
                : 09 February 2020
                : 10 February 2020
                Page count
                Figures: 3, Tables: 3, Pages: 14, Words: 8691
                Funding
                Funded by: National Key Research and Development Program of China , open-funder-registry 10.13039/501100012166;
                Funded by: Medical Health Science and Technology Project of Zhejiang Provincial Health Commission
                Award ID: 2018251644
                Funded by: Ministry of Science and Technology of the P. R. China; the National Natural Science Foundation of China
                Award ID: 81773521
                Funded by: National Key Research and Development Program of China , open-funder-registry 10.13039/501100012166;
                Award ID: 2016YFC0901405
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                April 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.8 mode:remove_FC converted:01.04.2020

                eq‐5d‐3l,esophageal cancer,health state utility,health‐related quality of life,multivariable linear regression

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