RAB11-mediated trafficking in host-pathogen interactions.

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Abstract

Many bacterial and viral pathogens block or subvert host cellular processes to promote successful infection. One host protein that is targeted by invading pathogens is the small GTPase RAB11, which functions in vesicular trafficking. RAB11 functions in conjunction with a protein complex known as the exocyst to mediate terminal steps in cargo transport via the recycling endosome to cell-cell junctions, phagosomes and cellular protrusions. These processes contribute to host innate immunity by promoting epithelial and endothelial barrier integrity, sensing and immobilizing pathogens and repairing pathogen-induced cellular damage. In this Review, we discuss the various mechanisms that pathogens have evolved to disrupt or subvert RAB11-dependent pathways as part of their infection strategy.

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Journal

Journal ID (iso-abbrev): Nat. Rev. Microbiol.

Title: Nature reviews. Microbiology

ISSN (Electronic): 1740-1534

ISSN (Print): 1740-1526

Publication date (Electronic): Sep 2014

Volume: 12

Issue: 9

Affiliations

[1 ] Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

[2 ] 1] Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. [2] Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

Article

Publisher Item ID: nrmicro3325 Mid ID: NIHMS650097

DOI: 10.1038/nrmicro3325

PMC ID: 4274738

PubMed ID: 25118884

SO-VID: c6d4e3d7-adf1-4236-a975-5679d30774bf

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