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      When expert opinion does matter...

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          Abstract

          The Roland Hetzer International Cardiothoracic and Vascular Surgery Society (RHICS), held its 2nd Expert Forum on February 11th 2012 in Freiburg, Germany, just three months after the 1st Expert Forum which took place in Lisbon, Portugal, in pursuit of its goals and objectives, which are to provide a forum for expert discussion on relevant cardiothoracic issues, to set up guidelines based on conclusions derived from this expert opinion forum, to promote cardiothoracic surgical education skills from beyond standardized and statistical medicine to a patient-based medicine wherein treatment approaches are individualized and personalized, and specific high-quality treatment tailored to the patient’s unique pathology so as to give them an optimal quality of life, after surgery, to promote continuing medical education through the holding of regular symposia and meetings and the continuance of clinical and experimental research efforts and the publication of the results in scientific journals, and to foster international collaboration and cooperation in clinical practice and scientific research in cardiothoracic and vascular surgery and associated fields. With numerous annual meetings, symposia, and conferences taking place in the field of cardiothoracic surgery, notwithstanding the hundreds of published expertise papers on new developments, ongoing researches, new technologies and techniques, surgical outcomes and its implications on clinical practice, when does an expert opinion matter? We are constantly bombarded with controversies in surgical options to manage cardiovascular diseases. What strategies to offer, which to repair, when to replace, for what disease, and for whom, seem to be eternal questions. Then again, which option gives the most acceptable, if not the most excellent, outcome, is of course, ever a matter of controversy. Most, if not all, published literature on a specific field in cardiothoracic surgery, would claim having the best outcome using the best technique for a certain subset of patients. The readers are left muddled up, whether their patients belong to those categorized in the published reports. We surf the internet but as we are all aware much of this material can be partially reliable and indeed often pitched at the wrong entry level and even far too complex for those new in the field. There are various editorials and commentaries we can search in Pubmed, but they may seem rather half-hearted to match what we are searching for covering some areas in great depth and others with less than a couple of bullet points. Surgical journals may sometimes let us down in our search for what we need. There is nothing quite like the mad pilgrimage to Black Hole followed by the terrible sinking feeling as you open pages after pages of journals, only to realise we do not understand a single word of concepts being discussed, or worst, we get even more confused. There must be a way to sum all these up, in a very concise manner, and from the mouths of the experts themselves. This is where an expert forum comes in. Expert opinions concentrate on driving back the boundaries of debates and controversies. It gives the audience or the readers an opportunity to take a fresh look at key issues through the eyes of people who know them best - masters and virtuosos, who are on the front line - to promote ideas and guidelines based on best practice from experts in their relevant fields. If we are to dramatically improve practice in our chosen fields, expert opinions from renowned surgeons, who put forward their Best Practice first-hand experience and suggestions, are priceless and much desired. Expert opinion aims to stimulate intellectual debate in key topics, whilst also offering a flagship for driving forward a truly logical and reproducible agenda. Hence, an expert opinion provides systematic and authoritative analysis to support every stage in our search for the best patient-based medicine. What makes expert forum really stand out is each paper presented concludes not with the “Conclusion” but with an “Expert Opinion”.  This is where our speakers, all internationally recognised experts in their field and key opinion leaders within the cardiothoracic field, give their own personal view. They put their knowledge, expertise and experience to the test, stating where the research is now, where it should go next, and how it should get there. And, because we recognise that there are two sides to every argument, participants and audience feedback is always welcome. In this issue of the Journal we publish five expert opinions [1,2,3,4,5] and three original articles [6,7,8] presented at the 2nd RHICS Expert Forum. We are certain that the readers (40% from North America, 50% from Europe and 10% from Asia and Australia in the last issue) will appreciate them as much as those who personally attended the Freiburg meeting.

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          Most cited references9

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          Impact of heart transplantation in infancy and adolescence on quality of life and compliance

          Introduction Young patients who undergo heart transplantation in their early childhood or adolescence are confronted with typical developmental problems, which affect their specific adjustment to heart transplantation. This study aims at evaluating patients’ health related quality of life and at determining the degree and sources of non-compliant behavior with its somatic and psychosocial consequences. Methods The study sample consists of 38 patients, who received heart transplantation between the age of 1 and 18 and are now between 16 and 34 years old. All participants received self-rating instruments: The Short-Form Health Survey (SF-36), Giessen Subjective Complaints List (GBB), Medication Experience Scale for Immunosuppressants (MESI), and Health Questionnaire for Children and Young People (KIDSCREEN-27). Patient´s scores were compared to the scores of the specific norm sample. Further assessment was done by semi-structured interviews directed at psychosocial outcome, compliance, relationship to family and peer-group and integration into the work environment. Results In comparison to healthy controls the patients showed a significantly reduced quality of life (SF-36) in all psychological and nearly all somatic domains. Patients emphasized a very close and satisfying relationship to their parents and pronounced overall social support. Almost 50% of the patients reported some reduced medical compliance and 20% are to be seen as a high risk group for noncompliance, simultaneously characterized by poor physical and mental status. Conclusion Young adult transplant patients are to be carefully evaluated for psychosocial risks to avoid noncompliance and reduced quality of life in long-term follow up.
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            Tissue engineered aortic valve

            P Dohmen (2012)
            Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation heart valve, which overcome limitations of biological and mechanical heart valves due to remodelling, regeneration and growth potential. Several publications are available in using tissue engineered heart valves in right ventricular outflow tract reconstruction. Limited experiences are available on these heart valves implanted into the systemic circulation. This overview shows the current state on the development of tissue engineered aortic heart valves.
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              Coarctation of the aorta

              Ding et al. report in the current number of the AMS [1] a 12 year old patient with abdominal coarctation of the aorta above the renal arteries treated successfully with percutanous transluminal angioplasty. This report is a useful reminder that hypertension maybe the sole manifestation of aortic coarctation that has an estimated incidence of 1 in 2500 live births [2] and may vary from a single constriction to a tubular hypoplasia of the aorta. The localization of the aortic constriction in this patient was in the abdominal aorta, above the renal arteries, and this variety or coarctation is rare (0.2-2.0%). Constriction of the aorta in this area is frequently associated, but not in this patient, with stenosis of renal, celiac or mesenteric arteries, causing the “middle-aortic dysplastic syndrome” or “middle-aortic syndrome” (MAS) that is a feature of several congenital and acquired clinical conditions [3]. The possibility of genetic factors is suggested by the report of the disease in monocygotic twins [4] and autosomal dominant inheritance in familial cases [5]. Gridlock mutations in the hey2 gen induce in the zebrafish changes similar to aortic coarctation that may be corrected with induced upregulation of vascular endothelial growth factor [6], but the relevance of these studies to human disease remain to be demonstrated. Other possible causes include the local accumulation of constricting fibrous tissue similar to that in arterial duct resulting from increased collagen gene expression induced locally by hemodynamic abnormalities in the distribution of the blood flow in the aorta [7–9]. Hypertension with absent pulses in the lower extremities was the clinical presentation of the patient described by Ding et al. [1] and the diagnosis was confirmed by computed tomography (CT) angiography. It is not unusual that patients are not diagnosed until adolescence or adulthood but it should be emphasized that an early diagnosis is important because the development of left ventricular hypertrophy and heart failure worsen the prognosis. Prenatal diagnosis of aortic coarctation is difficult and relays in serial fetal echocardiographic determinations of isthmal-ductal ratios [10] but neonatal diagnosis is possible and balloon dilatation has been used successfully in neonates weighing less than 2500 g with significant reduction of transcoarctation gradient [11]. However, restenosis is common and may develop rapidly. Repair of coarctation can be made by surgical correction (end to end anatomosis or subclavian flap repair to increase the size of the aorta) or by balloon angioplasty, with or without stent placement. In the patient reported by Ding et al. [1] the location and limited size of the constriction made it particularly amenable to angioplasty. Coarctation repair by balloon angioplasty has gained widespread acceptance despite a significant incidence of restenosis. Pooled data from the literature reviewed by Rao and Chopra [12] indicate that angioplasty has less rate of complications than surgical repair with respect to initial (7% vs. 23%) and late (2% vs. 25%) mortality and restenosis (11% vs. 18%). A particular concern in subclavian flap repair is the aneurysm formation that, if uncorrected, will rupture within 15 years [13]. Reported results from experienced groups indicate that 5–9 years after balloon angioplasty repair of the aortic coarctation located in the aortic arch, restenosis after occurs in approximately 80% of of neonates, two-thirds of infants and less than 10% in older children [14]. In the patient reported by Ding et al. [1] normal blood pressure was maintained more than 4 years after the angioplasty but longer follow up is mandatory since hypertension may reappear many years afterwards. Recent reports indicate that only half of the patients are normotensive two decades after repair procedures [15]. The lack of long-term success in the correction of hypertension is incompletely understood and abnormal compliance of aortic baroreceptors may play an important role [16]. The increased morbidity and mortality associated with late diagnosis of aortic coarctation requires increased awareness of the disease and the routine determination of blood pressure in neonates, infants and children. Magnetic resonance imaging is the most cost-effective diagnostic procedure in infants and older patients [17] and should be combined with neurological imaging to detect cerebral aneurysms that are present in 10% of the children with aortic coarctation [18]. Repair of aortic constriction is required when the transcatheter systolic coarctation gradient (TSCG) is > 20 mmHg as it was the case in this patient. The American Heart Association has established guidelines for the use of angioplasty in pediatric patients with and without stent placement [19]. Balloon angioplasty of native coarctation may be reasonable in patients beyond 4 to 6 months of age when associated with a TSCG > 20 mmHg and suitable anatomy. It may also indicated in patients with complex coarctation anatomy or systemic conditions such as connective tissue disease or Turner syndrome but decision should be made on a case-by-case basis. The placement of stents that may be expanded to adult size should be given consideration if there is a long segment of coarctation as well as in patients in whom balloon angioplasty has failed. It should be kept in mind that medical treatment is necessary in most patients before surgery and in many patients after surgery. The use of ramipril and atorvastatin reverses the impaired endothelial function and decreases the expression of proinflammatory cytokines and adhesion molecules in patients with aortic coarctation [20, 21]. A specific complication occurring sometimes after successful surgery repair is paradoxical hypertension. This complication is not due to activation of the renin angiotensin system and responds better to suppression of sympathetic activity with metoprolol [22]. The paper of Digh et al. [1] emphasizes the need to consider coarctation of abdominal aorta coarctation, a potentially curable condition, in the differential diagnosis of hypertension in young individuals.
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                Author and article information

                Journal
                HSR Proc Intensive Care Cardiovasc Anesth
                HSR Proc Intensive Care Cardiovasc Anesth
                2037-0504
                hsrp
                HSR Proceedings in Intensive Care & Cardiovascular Anesthesia
                EDIMES Edizioni Internazionali Srl
                2037-0504
                2037-0512
                2012
                : 4
                : 2
                : 69-71
                Affiliations
                Deutsches Herzzentrum Berlin, Berlin, Germany
                Author notes
                Eva Maria Delmo Walter Deutsches Herzzentrum Berlin Augustenburger Platz 1 13353 Berlin Germany; E-mail: delmo-walter@ 123456dhzb.de
                Article
                201202069
                3484935
                23441281
                c6a2445d-e750-492e-abe9-687627a6ccc5
                Copyright © 2012, HSR Proceedings in Intensive Care and Cardiovascular Anesthesia

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License 3.0, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode.

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