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Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway.
Mio Ikebe
1 ,
Yoshiki Kitaura ,
Masafumi Nakamura ,
Haruo Tanaka ,
Akio Yamasaki ,
Shuntaro Nagai ,
Junji Wada ,
Kosuke Yanai ,
Kenichiro Koga ,
Norihiro Sato ,
Makoto Kubo ,
Masao Tanaka ,
Hideya Onishi ,
Mitsuo Katano
Dec 15 2009
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Abstract
Inflammation plays a multifaceted role in cancer progression, and NF-kappaB is one of the key factors connecting inflammation with cancer progression. We have shown that lipopolysaccharide (LPS) promotes NF-kappaB activation in colon cancer cells and pancreatic cancer cells. However, it is unclear why inflammatory stimuli can induce NF-kappaB activation in cancer cells.