Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia

Highlights

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  Tumor-induced osteomalacia caused by culprit tumors in different parts of the body is a rare entity, resulting in great challenges to orthopedists.

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  Qualitative and localized diagnosis led by Multi-Disciplinary Team (MDT) is a prerequisite for subsequent surgical intervention.

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  Surgical treatment is the best treatment option for this disease, however, it may be quite difficult to remove the culprit tumor directly and surgical resection may bring huge damage.

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  Exploring the orthopedic surgical strategy for TIO is beneficial and critical for improving the treatment effects of orthopedic surgery and improve the prognosis of TIO patients.

Abstract

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is very rare, with about 1000 reported cases globally. Removing most TIO culprit tumors requires the evaluation and intervention of orthopedic doctors. However, orthopedic doctors often have a poor understanding of the optical treatment of TIO due to its rarity. In addition, most TIO patients lack specific clinical manifestations. Also, the clinical localization and qualitative diagnosis of TIO are difficult and thus can easily be misdiagnosed and mistreated. Furthermore, the true incidence rate of TIO may be underestimated. Although many breakthroughs have been made in exploring the pathogenesis, clinical diagnosis, and treatment of TIO, rational and standardized orthopedic surgical treatment experience summary and sorting for TIO patients are lacking. In this article, the recent experience and progress in the field of orthopedic surgical treatment for TIO globally have been summarized, providing a theoretical basis and new clinical practice guidance for the rational treatment of TIO patients.