Combined effect of tumor necrosis factor-alpha and ionizing radiation on the induction of apoptosis in 5637 bladder carcinoma cells.

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Abstract

Apoptosis can be induced by distinct but overlapping pathways. Ionizing radiation induces apoptosis by an "intrinsic", mitochondria-dependent pathway. Ligation of tumor necrosis factor-(TNF-)alpha, FAS (CD95) or TRAIL receptors are typical representatives of an extrinsic, death-receptor-mediated pathway. In this study the effect of irradiation, treatment with the cytokine TNF-alpha, or a combination of both on the induction of apoptosis and clonogenic survival of bladder carcinoma cells was investigated.

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Journal

Journal ID (iso-abbrev): Strahlenther Onkol

Title: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Publisher: Springer Nature America, Inc

ISSN: 0179-7158

ISSN (Print): 0179-7158

Publication date (Electronic): Aug 2006

Volume: 182

Issue: 8

Affiliations

[1 ] Department of Radiation Oncology, Friedrich Alexander University, Erlangen-Nuremberg, Erlangen, Germany.

Article

DOI: 10.1007/s00066-006-1475-2

PubMed ID: 16896593

SO-VID: c57112db-81a6-41b0-b320-b7e41eeeabbc

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