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HuR and mRNA stability :
February 2001
February 2001
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Abstract
An important mechanism of posttranscriptional gene regulation in mammalian cells is
the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs)
in their 3' untranslated regions. HuR, a ubiquitously expressed member of the Hu family
of RNA-binding proteins related to Drosophila ELAV, selectively binds AREs and stabilizes
ARE-containing mRNAs when overexpressed in cultured cells. This review discusses mRNA
decay as a general form of gene regulation, decay signaled by AREs, and the role of
HuR and its Hu-family relatives in antagonizing this mRNA degradation pathway. The
influence of newly identified protein ligands to HuR on HuR function in both normal
and stressed cells may explain how ARE-mediated mRNA decay is regulated in response
to environmental change.