Obtaining high-quality biopsy specimens is crucial for accurate diagnosis and treatment planning. The SuperCoreAdvantage™side notch semi-automatic biopsy device, developed by Argon Medical Devices, is a novel side notch semi-automatic biopsy device that offers optimized tissue sampling with minimal fragmentation and preserved tissue architecture. This case series aims to showcase the efficacy of the SuperCoreAdvantage™device in two cases involving different anatomical locations. Additionally, the series discusses the significance of reducing dead space in biopsy needle design to improve histologic sampling and diagnostic accuracy.