Clinical study of Edaravone Dexborneol combined with Tirofiban in treatment of Acute Cerebral Infarction

Abstract

Objective:

To explore the clinical efficacy and safety of edaravone dexborneol combined with tirofiban in the treatment of acute cerebral infarction.

Methods:

This is a retrospective study. A total of 80 patients with acute cerebral infarction (ACI) treated in Cangzhou People’s Hospital from March 2018 to December 2021 were selected, and randomly divided into the routine group(n=40) and intervention group(n=40) according to the principle of random draw. Neurological deficits in the two groups were evaluated and compared before and after treatment using the National Institutes of Health Stroke Scale (NIHSS). The quality of life of the patients was evaluated by the modified Rankin Scale (mRS).

Results:

Before treatment, NIHSS and mRS scores of the two groups were not statistically significant( p>0.05); the levels of Vmin and Qmin in the two groups showed no statistical significance( p>0.05); no statistical significance was found in CRP or IL-6 levels between the two groups( p>0.05). After treatment for 14 days, the NIHSS and mRS scores of the two groups both decreased, which was more significant in the intervention group( p<0.05); Vmin and Qmin levels increased in both groups, which was more obvious in the intervention group( p<0.05); CRP and IL-6 levels reduced in both groups, which was more remarkable in the intervention group( p<0.05). The incidences of relevant adverse drug reactions presented no differences between the two groups during treatment( p>0.05).

Conclusion:

Edaravone dexborneol combined with tirofiban in the treatment of ACI can effectively improve patients’ neurological deficits, quality of life and cerebral blood flow, and reduce inflammatory factor levels, have significant clinical efficacy and high clinical treatment safety.