Safety and biodistribution study of bone marrow-derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model.

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Abstract

Bone marrow mononuclear cells (BM-MNCs) and bone marrow-derived mesenchymal stem stromal cells (BM-MSCs) could have therapeutic potential for numerous conditions, including ischemia-related injury. Cells transplanted intravascularly may become entrapped in the lungs, which potentially decreases their therapeutic effect and increases the risk for embolism.

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Author and article information

Journal

Journal ID (iso-abbrev): Cytotherapy

Title: Cytotherapy

ISSN (Electronic): 1477-2566

ISSN (Print): 1465-3249

Publication date (Electronic): Apr 2015

Volume: 17

Issue: 4

Affiliations

[1 ] Department of Surgery, Oulu University Hospital, Oulu, Finland. Electronic address: tuomas.makela@oulu.fi.

[2 ] Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.

[3 ] Department of Surgery, Oulu University Hospital, Oulu, Finland.

[4 ] Department of Anaesthesiology, Oulu University Hospital, Oulu, Finland.

[5 ] Finnish Red Cross Blood Service, Research and Cell Therapy Services, Helsinki, Finland.

[6 ] Department of Anatomy and Cell Biology, Medical Research Center, University of Oulu, Oulu, Finland.

Article

Publisher Item ID: S1465-3249(14)00884-6

DOI: 10.1016/j.jcyt.2014.12.004

PubMed ID: 25601140

SO-VID: c2e395b8-57a4-4949-872d-b1e96bc11500

History

Keywords: biodistribution,imaging,stem cells

Data availability:

Keywords: biodistribution, imaging, stem cells

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