Guchang Zhixie Wan protects mice against dextran sulfate sodium-induced colitis through modulating the gut microbiota in colon.

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Abstract

Guchang Zhixie Wan (GC) is a traditional Chinese patent medicine used in the treatment of colitis in clinical trials. Though the notable effect of GC on colitis, the concrete mechanism of GC remain elusive. Emerging evidence showed that the imbalances of inflammatory cytokines and gut microbiota were both closely related to the initiation and progression of colitis.

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Author and article information

Journal

Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): Oct 05 2020

Volume: 260

Affiliations

[1 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: wazh0405@126.com.

[2 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: aiziji_2005@126.com.

[3 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: jingaoyu@sina.cn.

[4 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: symensu@163.com.

[5 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: 853952325@qq.com.

[6 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: zhzh626@outlook.com.

[7 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: 728847329@qq.com.

[8 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: wuxue0820@163.com.

[9 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: liuyan791@163.com.

[10 ] Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine, Xianyang, 712083, China. Electronic address: tzs6565@163.com.

Article

Publisher Item ID: S0378-8741(19)32517-6

DOI: 10.1016/j.jep.2020.112991

PubMed ID: 32442592

SO-VID: c27f6c19-688a-4aee-8c02-693fd86f549d

History

Keywords: Gut microbiota,DSS,GC,Inflammation,Colitis

Data availability:

Keywords: Gut microbiota, DSS, GC, Inflammation, Colitis

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